No evidence for association of familial parkinson's disease with cag repeat expansion

R. Carrero-Valenzuela, K. Lindblad, H. Payami, W. Johnson, M. Schalling, E. S. Stenroos, S. Shattuc, J. Nutt, A. Brice, M. Litt

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation.Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.

Original languageEnglish (US)
Pages (from-to)1760-1763
Number of pages4
JournalNeurology
Volume45
Issue number9
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Clinical Neurology

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