No evidence for association of familial Parkinson's disease with CAG repeat expansion

R. Carrero-Valenzuela; K. Lindblad; H. Payami; W. Johnson; M. Schalling; E. S. Stenroos; S. Shattuc; J. Nutt; A. Brice; M. Litt

No evidence for association of familial Parkinson's disease with CAG repeat expansion

R. Carrero-Valenzuela, K. Lindblad, H. Payami, W. Johnson, M. Schalling, E. S. Stenroos, S. Shattuc, J. Nutt, A. Brice, M. Litt

Neurology

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30 Scopus citations

Abstract

In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation. Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.

Original language	English (US)
Pages (from-to)	1760-1763
Number of pages	4
Journal	Neurology
Volume	45
Issue number	9
State	Published - Sep 1995

ASJC Scopus subject areas

Clinical Neurology

Cite this

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title = "No evidence for association of familial Parkinson's disease with CAG repeat expansion",

abstract = "In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation. Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.",

author = "R. Carrero-Valenzuela and K. Lindblad and H. Payami and W. Johnson and M. Schalling and Stenroos, {E. S.} and S. Shattuc and J. Nutt and A. Brice and M. Litt",

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T1 - No evidence for association of familial Parkinson's disease with CAG repeat expansion

AU - Carrero-Valenzuela, R.

AU - Lindblad, K.

AU - Payami, H.

AU - Johnson, W.

AU - Schalling, M.

AU - Stenroos, E. S.

AU - Shattuc, S.

AU - Nutt, J.

AU - Brice, A.

AU - Litt, M.

PY - 1995/9

Y1 - 1995/9

N2 - In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation. Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.

AB - In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation. Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.

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M3 - Article

C2 - 7675242

AN - SCOPUS:0028787434

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JO - Neurology

JF - Neurology

IS - 9

ER -

No evidence for association of familial Parkinson's disease with CAG repeat expansion

Abstract

ASJC Scopus subject areas

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