No evidence for association of familial parkinson's disease with cag repeat expansion

R. Carrero-Valenzuela, K. Lindblad, H. Payami, W. Johnson, M. Schalling, E. S. Stenroos, S. Shattuc, John Nutt, A. Brice, M. Litt

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation.Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.

Original languageEnglish (US)
Pages (from-to)1760-1763
Number of pages4
JournalNeurology
Volume45
Issue number9
StatePublished - 1995

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Parkinson Disease
Genetic Anticipation
Age of Onset
Repeats
Parkinson's Disease
Familial
Anticipation
Parkinson Disease 11

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Carrero-Valenzuela, R., Lindblad, K., Payami, H., Johnson, W., Schalling, M., Stenroos, E. S., ... Litt, M. (1995). No evidence for association of familial parkinson's disease with cag repeat expansion. Neurology, 45(9), 1760-1763.

No evidence for association of familial parkinson's disease with cag repeat expansion. / Carrero-Valenzuela, R.; Lindblad, K.; Payami, H.; Johnson, W.; Schalling, M.; Stenroos, E. S.; Shattuc, S.; Nutt, John; Brice, A.; Litt, M.

In: Neurology, Vol. 45, No. 9, 1995, p. 1760-1763.

Research output: Contribution to journalArticle

Carrero-Valenzuela, R, Lindblad, K, Payami, H, Johnson, W, Schalling, M, Stenroos, ES, Shattuc, S, Nutt, J, Brice, A & Litt, M 1995, 'No evidence for association of familial parkinson's disease with cag repeat expansion', Neurology, vol. 45, no. 9, pp. 1760-1763.
Carrero-Valenzuela R, Lindblad K, Payami H, Johnson W, Schalling M, Stenroos ES et al. No evidence for association of familial parkinson's disease with cag repeat expansion. Neurology. 1995;45(9):1760-1763.
Carrero-Valenzuela, R. ; Lindblad, K. ; Payami, H. ; Johnson, W. ; Schalling, M. ; Stenroos, E. S. ; Shattuc, S. ; Nutt, John ; Brice, A. ; Litt, M. / No evidence for association of familial parkinson's disease with cag repeat expansion. In: Neurology. 1995 ; Vol. 45, No. 9. pp. 1760-1763.
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