Abstract
In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation.Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1760-1763 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 45 |
| Issue number | 9 |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
No evidence for association of familial parkinson's disease with cag repeat expansion. / Carrero-Valenzuela, R.; Lindblad, K.; Payami, H.; Johnson, W.; Schalling, M.; Stenroos, E. S.; Shattuc, S.; Nutt, John; Brice, A.; Litt, M.
In: Neurology, Vol. 45, No. 9, 1995, p. 1760-1763.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No evidence for association of familial parkinson's disease with cag repeat expansion
AU - Carrero-Valenzuela, R.
AU - Lindblad, K.
AU - Payami, H.
AU - Johnson, W.
AU - Schalling, M.
AU - Stenroos, E. S.
AU - Shattuc, S.
AU - Nutt, John
AU - Brice, A.
AU - Litt, M.
PY - 1995
Y1 - 1995
N2 - In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation.Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.
AB - In some kindreds, familial Parkinson's disease (PD) exhibits genetic anticipation.Thus, we postulated that familial PD in certain kindreds may be associated with a CAG repeat expansion. However, using the repeat expansion detection method, we found no significant increase in the frequency of CAG repeat expansion among 46 unrelated PD probands compared with controls. Nor did we find evidence for CAG repeat expansion between generations in 11 different PD families that exhibit anticipation in age at onset.
UR - http://www.scopus.com/inward/record.url?scp=0028787434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028787434&partnerID=8YFLogxK
M3 - Article
C2 - 7675242
AN - SCOPUS:0028787434
VL - 45
SP - 1760
EP - 1763
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 9
ER -