New sites of action for GIRK and SK channels

Rafael Luján, James Maylie, John P. Adelman

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

It was recently discovered that two different types of voltage-insensitive K + channels, G protein-coupled inwardly rectifying K + (GIRK) and small-conductance Ca 2+-activated K + (SK) channels, are located on dendritic branches, spines and shafts in the postsynaptic densities of excitatory synapses in many central neurons. Together with increases in our knowledge of how these channels are regulated through stable protein-protein interactions in multi-protein complexes, this has added another layer of complexity to our understanding of synaptic transmission and plasticity.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalNature Reviews Neuroscience
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2009

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ASJC Scopus subject areas

  • Neuroscience(all)

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