New sites of action for GIRK and SK channels

Rafael Luján, James Maylie, John Adelman

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

It was recently discovered that two different types of voltage-insensitive K + channels, G protein-coupled inwardly rectifying K + (GIRK) and small-conductance Ca 2+-activated K + (SK) channels, are located on dendritic branches, spines and shafts in the postsynaptic densities of excitatory synapses in many central neurons. Together with increases in our knowledge of how these channels are regulated through stable protein-protein interactions in multi-protein complexes, this has added another layer of complexity to our understanding of synaptic transmission and plasticity.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalNature Reviews Neuroscience
Volume10
Issue number7
DOIs
StatePublished - Jul 2009

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Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Post-Synaptic Density
Dendritic Spines
Proteins
Neuronal Plasticity
Synaptic Transmission
Synapses
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

New sites of action for GIRK and SK channels. / Luján, Rafael; Maylie, James; Adelman, John.

In: Nature Reviews Neuroscience, Vol. 10, No. 7, 07.2009, p. 475-480.

Research output: Contribution to journalArticle

Luján, Rafael ; Maylie, James ; Adelman, John. / New sites of action for GIRK and SK channels. In: Nature Reviews Neuroscience. 2009 ; Vol. 10, No. 7. pp. 475-480.
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