TY - JOUR
T1 - New insights into the ontogeny of breathing from genetically engineered mice
AU - Katz, David M.
AU - Balkowiec, Agnieszka
PY - 1997
Y1 - 1997
N2 - Development of breathing behavior depends on the coordinated maturation of central and peripheral neural pathways, respiratory muscles, airways, and lung tissues. Each of these components contains cellular elements in which derangements of gene expression may perturb development of normal respiratory function. Application in recent years of genetic engineering techniques has led to detailed analyses of gene structure and function. In particular, targeted gene deletions provide the opportunity to relate gene function to physiologic mechanisms in intact animals. This review summarizes recent studies in mice designed to alter, by targeted disruption of specific genes, development of individual components of the respiratory control system. We also discuss an example of the human therapeutic potential of transgenic methods.
AB - Development of breathing behavior depends on the coordinated maturation of central and peripheral neural pathways, respiratory muscles, airways, and lung tissues. Each of these components contains cellular elements in which derangements of gene expression may perturb development of normal respiratory function. Application in recent years of genetic engineering techniques has led to detailed analyses of gene structure and function. In particular, targeted gene deletions provide the opportunity to relate gene function to physiologic mechanisms in intact animals. This review summarizes recent studies in mice designed to alter, by targeted disruption of specific genes, development of individual components of the respiratory control system. We also discuss an example of the human therapeutic potential of transgenic methods.
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U2 - 10.1097/00063198-199711000-00009
DO - 10.1097/00063198-199711000-00009
M3 - Article
C2 - 9391764
AN - SCOPUS:0031263386
SN - 1070-5287
VL - 3
SP - 433
EP - 439
JO - Current opinion in pulmonary medicine
JF - Current opinion in pulmonary medicine
IS - 6
ER -