New focus on alpha-crystallins in retinal neurodegenerative diseases

Patrice E. Fort; Kirsten J. Lampi

doi:10.1016/j.exer.2010.11.008

New focus on alpha-crystallins in retinal neurodegenerative diseases

Patrice E. Fort, Kirsten J. Lampi

School of Dentistry

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

The crystallin proteins were initially identified as structural proteins of the ocular lens and have been recently demonstrated to be expressed in normal retina. They are dramatically upregulated by a large range of retinal diseases including diabetic retinopathy, age-related macular degeneration, uveitis, trauma and ischemia. The crystallin family of proteins is composed of alpha-, beta- and gamma-crystallin. Alpha-crystallins, which are small heat shock proteins, have received substantial attention recently. This review summarizes the current knowledge of alpha-crystallins in retinal diseases, their roles in retinal neuron cell survival and retinal inflammation, and the regulation of their expression and activity. Their potential role in the development of new treatments for neurodegenerative diseases is also discussed.

Original language	English (US)
Pages (from-to)	98-103
Number of pages	6
Journal	Experimental Eye Research
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/j.exer.2010.11.008
State	Published - Feb 2011

Keywords

Apoptosis
Crystallins
Neurodegeneration
Retinal diseases

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/j.exer.2010.11.008

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title = "New focus on alpha-crystallins in retinal neurodegenerative diseases",

abstract = "The crystallin proteins were initially identified as structural proteins of the ocular lens and have been recently demonstrated to be expressed in normal retina. They are dramatically upregulated by a large range of retinal diseases including diabetic retinopathy, age-related macular degeneration, uveitis, trauma and ischemia. The crystallin family of proteins is composed of alpha-, beta- and gamma-crystallin. Alpha-crystallins, which are small heat shock proteins, have received substantial attention recently. This review summarizes the current knowledge of alpha-crystallins in retinal diseases, their roles in retinal neuron cell survival and retinal inflammation, and the regulation of their expression and activity. Their potential role in the development of new treatments for neurodegenerative diseases is also discussed.",

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AB - The crystallin proteins were initially identified as structural proteins of the ocular lens and have been recently demonstrated to be expressed in normal retina. They are dramatically upregulated by a large range of retinal diseases including diabetic retinopathy, age-related macular degeneration, uveitis, trauma and ischemia. The crystallin family of proteins is composed of alpha-, beta- and gamma-crystallin. Alpha-crystallins, which are small heat shock proteins, have received substantial attention recently. This review summarizes the current knowledge of alpha-crystallins in retinal diseases, their roles in retinal neuron cell survival and retinal inflammation, and the regulation of their expression and activity. Their potential role in the development of new treatments for neurodegenerative diseases is also discussed.

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New focus on alpha-crystallins in retinal neurodegenerative diseases

Abstract

Keywords

ASJC Scopus subject areas

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