New focus on alpha-crystallins in retinal neurodegenerative diseases

Patrice E. Fort, Kirsten J. Lampi

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

The crystallin proteins were initially identified as structural proteins of the ocular lens and have been recently demonstrated to be expressed in normal retina. They are dramatically upregulated by a large range of retinal diseases including diabetic retinopathy, age-related macular degeneration, uveitis, trauma and ischemia. The crystallin family of proteins is composed of alpha-, beta- and gamma-crystallin. Alpha-crystallins, which are small heat shock proteins, have received substantial attention recently. This review summarizes the current knowledge of alpha-crystallins in retinal diseases, their roles in retinal neuron cell survival and retinal inflammation, and the regulation of their expression and activity. Their potential role in the development of new treatments for neurodegenerative diseases is also discussed.

Original languageEnglish (US)
Pages (from-to)98-103
Number of pages6
JournalExperimental Eye Research
Volume92
Issue number2
DOIs
StatePublished - Feb 1 2011

Keywords

  • Apoptosis
  • Crystallins
  • Neurodegeneration
  • Retinal diseases

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'New focus on alpha-crystallins in retinal neurodegenerative diseases'. Together they form a unique fingerprint.

  • Cite this