Neutrophil CD64 expression: Distinguishing acute inflammatory autoimmune disease from systemic infections

Elizabeth Allen, A. C. Bakke, M. Z. Purtzer, Atulya (Atul) Deodhar

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: Common bacterial and opportunistic infections are a major cause of mortality in patients who are immunosuppressed owing to treatment with corticosteroids or cytotoxic drugs. Common laboratory tests for infection lack sensitivity and specificity. One of the new generation of tests to detect early systemic infections measures the up regulation of an Fc receptor (Fcγ R1, or CD64) on neutrophils. The Fc receptors on white blood cells are very important for effective phagocytosis of bacteria and are up regulated during an infection. Objective: To measure the clinical usefulness of quantitative CD64 measurements to differentiate between systemic infection and active autoimmune inflammation in an ongoing study. Methods: Patients with systemic infection (n=27), active autoimmune inflammatory disease (n=44), vasculitis (n=5), and controls (n=20) were studied for neutrophil CD64 expression using monoclonal antibodies and flow cytometry. Results: The median (interquartile range (IQR)) CD64 expression in patients with active inflammatory disease and systemic infection was 907.5 (586-1550) and 3647 (2380-6642), respectively (p

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume61
Issue number6
DOIs
StatePublished - 2002

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Fc Receptors
Autoimmune Diseases
Neutrophils
Flow cytometry
Infection
Bacteria
Adrenal Cortex Hormones
Blood
Monoclonal Antibodies
Cells
Laboratory Infection
Pharmaceutical Preparations
Opportunistic Infections
Vasculitis
Phagocytosis
Bacterial Infections
Flow Cytometry
Leukocytes
Up-Regulation
Inflammation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Neutrophil CD64 expression : Distinguishing acute inflammatory autoimmune disease from systemic infections. / Allen, Elizabeth; Bakke, A. C.; Purtzer, M. Z.; Deodhar, Atulya (Atul).

In: Annals of the Rheumatic Diseases, Vol. 61, No. 6, 2002, p. 522-525.

Research output: Contribution to journalArticle

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