Neurotoxicity of pesticides

A brief review

Lucio G. Costa, Gennaro Giordano, Marina Guizzetti, Annabella Vitalone

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Pesticides are substances widely used to control unwanted pests such as insects, weeds, fungi and rodents. Most pesticides are not highly selective, and are also toxic to nontarget species, including humans. A number of pesticides can cause neurotoxicity. Insecticides, which kill insects by targeting their nervous system, have neurotoxic effect in mammals as well. This family of chemicals comprises the organophosphates, the carbamates, the pyrethroids, the organochlorines, and other compounds. Insecticides interfere with chemical neurotransmission or ion channels, and usually cause reversible neurotoxic effects, that could nevertheless be lethal. Some herbicides and fungicides have also been shown to possess neurotoxic properties. The effects of pesticides on the nervous system may be involved in their acute toxicity, as in case of most insecticides, or may contribute to chronic neurodegenerative disorders, most notably Parkinson's disease. This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action.

Original languageEnglish (US)
Pages (from-to)1240-1249
Number of pages10
JournalFrontiers in bioscience : a journal and virtual library
Volume13
Issue number4
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Pesticides
Insecticides
Neurology
Pesticide effects
Nervous System
Pest control
Insects
Fungicides
Pyrethrins
Mammals
Carbamates
Organophosphates
Poisons
Herbicides
Chlorinated Hydrocarbons
Fungi
Pest Control
Ion Channels
Toxicity
Synaptic Transmission

Keywords

  • Insecticides
  • Neurotoxicity
  • Organophosphates
  • Pesticides
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Medicine(all)

Cite this

Neurotoxicity of pesticides : A brief review. / Costa, Lucio G.; Giordano, Gennaro; Guizzetti, Marina; Vitalone, Annabella.

In: Frontiers in bioscience : a journal and virtual library, Vol. 13, No. 4, 2008, p. 1240-1249.

Research output: Contribution to journalArticle

Costa, Lucio G. ; Giordano, Gennaro ; Guizzetti, Marina ; Vitalone, Annabella. / Neurotoxicity of pesticides : A brief review. In: Frontiers in bioscience : a journal and virtual library. 2008 ; Vol. 13, No. 4. pp. 1240-1249.
@article{79a2549d0db4484a84c4e8bb4728b1e6,
title = "Neurotoxicity of pesticides: A brief review",
abstract = "Pesticides are substances widely used to control unwanted pests such as insects, weeds, fungi and rodents. Most pesticides are not highly selective, and are also toxic to nontarget species, including humans. A number of pesticides can cause neurotoxicity. Insecticides, which kill insects by targeting their nervous system, have neurotoxic effect in mammals as well. This family of chemicals comprises the organophosphates, the carbamates, the pyrethroids, the organochlorines, and other compounds. Insecticides interfere with chemical neurotransmission or ion channels, and usually cause reversible neurotoxic effects, that could nevertheless be lethal. Some herbicides and fungicides have also been shown to possess neurotoxic properties. The effects of pesticides on the nervous system may be involved in their acute toxicity, as in case of most insecticides, or may contribute to chronic neurodegenerative disorders, most notably Parkinson's disease. This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action.",
keywords = "Insecticides, Neurotoxicity, Organophosphates, Pesticides, Review",
author = "Costa, {Lucio G.} and Gennaro Giordano and Marina Guizzetti and Annabella Vitalone",
year = "2008",
doi = "10.2741/2758",
language = "English (US)",
volume = "13",
pages = "1240--1249",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "4",

}

TY - JOUR

T1 - Neurotoxicity of pesticides

T2 - A brief review

AU - Costa, Lucio G.

AU - Giordano, Gennaro

AU - Guizzetti, Marina

AU - Vitalone, Annabella

PY - 2008

Y1 - 2008

N2 - Pesticides are substances widely used to control unwanted pests such as insects, weeds, fungi and rodents. Most pesticides are not highly selective, and are also toxic to nontarget species, including humans. A number of pesticides can cause neurotoxicity. Insecticides, which kill insects by targeting their nervous system, have neurotoxic effect in mammals as well. This family of chemicals comprises the organophosphates, the carbamates, the pyrethroids, the organochlorines, and other compounds. Insecticides interfere with chemical neurotransmission or ion channels, and usually cause reversible neurotoxic effects, that could nevertheless be lethal. Some herbicides and fungicides have also been shown to possess neurotoxic properties. The effects of pesticides on the nervous system may be involved in their acute toxicity, as in case of most insecticides, or may contribute to chronic neurodegenerative disorders, most notably Parkinson's disease. This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action.

AB - Pesticides are substances widely used to control unwanted pests such as insects, weeds, fungi and rodents. Most pesticides are not highly selective, and are also toxic to nontarget species, including humans. A number of pesticides can cause neurotoxicity. Insecticides, which kill insects by targeting their nervous system, have neurotoxic effect in mammals as well. This family of chemicals comprises the organophosphates, the carbamates, the pyrethroids, the organochlorines, and other compounds. Insecticides interfere with chemical neurotransmission or ion channels, and usually cause reversible neurotoxic effects, that could nevertheless be lethal. Some herbicides and fungicides have also been shown to possess neurotoxic properties. The effects of pesticides on the nervous system may be involved in their acute toxicity, as in case of most insecticides, or may contribute to chronic neurodegenerative disorders, most notably Parkinson's disease. This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action.

KW - Insecticides

KW - Neurotoxicity

KW - Organophosphates

KW - Pesticides

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=38449123157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449123157&partnerID=8YFLogxK

U2 - 10.2741/2758

DO - 10.2741/2758

M3 - Article

VL - 13

SP - 1240

EP - 1249

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 4

ER -