Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane.

L. C. Sheldahl, L. K. Marriott, D. M. Bryant, R. A. Shapiro, Daniel Dorsa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalMinerva Endocrinologica
Volume32
Issue number2
StatePublished - Jun 2007

Fingerprint

Selective Estrogen Receptor Modulators
Neuroprotective Agents
Estrogens
Cell Membrane
Hormone Replacement Therapy
Estrogen Receptors
Membranes
Brain
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane. / Sheldahl, L. C.; Marriott, L. K.; Bryant, D. M.; Shapiro, R. A.; Dorsa, Daniel.

In: Minerva Endocrinologica, Vol. 32, No. 2, 06.2007, p. 87-94.

Research output: Contribution to journalArticle

Sheldahl, L. C. ; Marriott, L. K. ; Bryant, D. M. ; Shapiro, R. A. ; Dorsa, Daniel. / Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane. In: Minerva Endocrinologica. 2007 ; Vol. 32, No. 2. pp. 87-94.
@article{34dd4d2ff29e450da2d7dbcbcdfea18a,
title = "Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane.",
abstract = "Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.",
author = "Sheldahl, {L. C.} and Marriott, {L. K.} and Bryant, {D. M.} and Shapiro, {R. A.} and Daniel Dorsa",
year = "2007",
month = "6",
language = "English (US)",
volume = "32",
pages = "87--94",
journal = "Minerva Endocrinologica",
issn = "0391-1977",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

TY - JOUR

T1 - Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane.

AU - Sheldahl, L. C.

AU - Marriott, L. K.

AU - Bryant, D. M.

AU - Shapiro, R. A.

AU - Dorsa, Daniel

PY - 2007/6

Y1 - 2007/6

N2 - Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.

AB - Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.

UR - http://www.scopus.com/inward/record.url?scp=34948876458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34948876458&partnerID=8YFLogxK

M3 - Article

C2 - 17557034

AN - SCOPUS:34948876458

VL - 32

SP - 87

EP - 94

JO - Minerva Endocrinologica

JF - Minerva Endocrinologica

SN - 0391-1977

IS - 2

ER -