Neuroprotective effects of estrogen and selective estrogen receptor modulators begin at the plasma membrane.

L. C. Sheldahl, L. K. Marriott, D. M. Bryant, R. A. Shapiro, D. M. Dorsa

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Estrogen is neuroprotective in a large number of models in vivo and in vitro. Its application in hormone replacement therapy has proven to be more complicated, necessitating better understanding of how estrogen signals in the brain. Estrogen binds to estrogen receptors to regulate gene transcription, and activates a number of rapid signaling cascades from the plasma membrane. These rapid signaling cascades have been shown to play important roles in mediating the neuroprotective effects of estrogen. This review covers evidence that understanding and targeting the membrane effects of estrogen has emerged as an important area in the design of novel neuroprotective drugs.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalMinerva endocrinologica
Volume32
Issue number2
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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