Neurons in the cochlear nuclei controlling the tensor tympani muscle in the rat: A study using pseudorabies virus

I. Billig, M. S. Yeager, A. Blikas, Yael Raz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The middle ear muscle reflex has been implicated in modulation of auditory input and protection of the inner ear from acoustic trauma. However, the identification of neurons in the cochlear nuclei participating in this reflex has not been fully elucidated. In the present study, we injected the retrograde transynaptic tracer pseudorabies virus into single tensor tympani (TT) muscles, and identified transynaptically labeled cochlear nucleus neurons at multiple survival times. Motoneurons controlling TT were located ventral to the ipsilateral motor trigeminal nucleus and extended rostrally towards the medial aspect of the lateral lemniscus. Transynaptically labeled neurons were observed bilaterally in the dorsal and dorso-medial parts of ventral cochlear nuclei as early as 48 h after virus injection, and had morphological features of radiate multipolar cells. After ≥ 69 h, labeled cells of different types were observed in all cochlear nuclei. At those times, labeling was also detected bilaterally in the medial nucleus of the trapezoid body and periolivary cell groups in the superior olivary complex. Based on the temporal course of viral replication, our data strongly suggest the presence of a direct projection of neurons from the ventral cochlear nuclei bilaterally to the TT motoneuron pool in rats. The influence of neurons in the cochlear nuclei upon TT activity through direct and indirect pathways may account for multifunctional roles of this muscle in auditory functions.

Original languageEnglish (US)
Pages (from-to)124-136
Number of pages13
JournalBrain Research
Volume1154
Issue number1
DOIs
StatePublished - Jun 18 2007
Externally publishedYes

Fingerprint

Tensor Tympani
Suid Herpesvirus 1
Cochlear Nucleus
Neurons
Muscles
Motor Neurons
Reflex
Noise-Induced Hearing Loss
Middle Ear
Inner Ear
Viruses
Injections

Keywords

  • Direct and indirect acoustic reflex pathways
  • Middle ear muscle
  • Transynaptic transport

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Neurons in the cochlear nuclei controlling the tensor tympani muscle in the rat : A study using pseudorabies virus. / Billig, I.; Yeager, M. S.; Blikas, A.; Raz, Yael.

In: Brain Research, Vol. 1154, No. 1, 18.06.2007, p. 124-136.

Research output: Contribution to journalArticle

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