Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes

Jingru Sun, Varsha Singh, Rie Kajino-Sakamoto, Alejandro Aballay

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.

Original languageEnglish (US)
Pages (from-to)729-732
Number of pages4
JournalScience
Volume332
Issue number6030
DOIs
StatePublished - May 6 2011

ASJC Scopus subject areas

  • General

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