Neuroleptic sensitivity to clozapine in dementia with Lewy bodies

William J. Burke; Ronald F. Pfeiffer; Rodney D. McComb

doi:10.1176/jnp.10.2.227

Neuroleptic sensitivity to clozapine in dementia with Lewy bodies

William J. Burke, Ronald F. Pfeiffer, Rodney D. McComb

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because halucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.

Original language	English (US)
Pages (from-to)	227-229
Number of pages	3
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	10
Issue number	2
DOIs	https://doi.org/10.1176/jnp.10.2.227
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1176/jnp.10.2.227

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abstract = "Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because halucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.",

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AU - McComb, Rodney D.

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AB - Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because halucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.

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Neuroleptic sensitivity to clozapine in dementia with Lewy bodies

Abstract

ASJC Scopus subject areas

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