TY - JOUR
T1 - Neurodevelopmental Effects of Antiepileptic Drugs
AU - Kellogg, Marissa
AU - Meador, Kimford J.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York (outside the USA).
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during critical periods of development may induce transient or long-lasting neurodevelopmental deficits across cognitive, motor and behavioral domains. The developing nervous system may endure prolonged chronic exposure to AEDs during pregnancy (in utero) or during childhood, which can lead to neurodevelopmental defects such as congenital neural tube defects, lower IQ, language deficits, autism and ADHD. To date, valproate is the most widely recognized AED to significantly negatively affect neurodevelopment, and demonstrates greater adverse effects than any other AEDs that have been assessed. Although some AEDs appear to have low risk (i.e., lamotrigine, levetiracetam), other AEDs have been implicated in a variety of studies detailed below, and many AEDs have not been adequately assessed. The purpose of this review article is to summarize our current understanding of the neurodevelopmental effects of AEDs.
AB - Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during critical periods of development may induce transient or long-lasting neurodevelopmental deficits across cognitive, motor and behavioral domains. The developing nervous system may endure prolonged chronic exposure to AEDs during pregnancy (in utero) or during childhood, which can lead to neurodevelopmental defects such as congenital neural tube defects, lower IQ, language deficits, autism and ADHD. To date, valproate is the most widely recognized AED to significantly negatively affect neurodevelopment, and demonstrates greater adverse effects than any other AEDs that have been assessed. Although some AEDs appear to have low risk (i.e., lamotrigine, levetiracetam), other AEDs have been implicated in a variety of studies detailed below, and many AEDs have not been adequately assessed. The purpose of this review article is to summarize our current understanding of the neurodevelopmental effects of AEDs.
KW - AED
KW - AED exposure
KW - Anticonvulsant drugs
KW - Antiepileptic drugs
KW - Neurodevelopment
KW - Neurodevelopmental effects
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U2 - 10.1007/s11064-017-2262-4
DO - 10.1007/s11064-017-2262-4
M3 - Article
C2 - 28424947
AN - SCOPUS:85018511410
SN - 0364-3190
VL - 42
SP - 2065
EP - 2070
JO - Neurochemical Research
JF - Neurochemical Research
IS - 7
ER -