Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides

T. M. Farahat, G. M. Abdelrasoul, M. M. Amr, M. M. Shebl, F. M. Farahat, Wyndham Anger

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Aims: To identify neurobehavioural deficits among workers exposed to organophosphorous (OP) pesticides in their occupation. Methods: This study was conducted during the period when pesticides were applied to cotton crops in the fields in Menoufiya Governorate, Egypt. Fifty two occupationally exposed male workers were compared to 50 unexposed male controls who were similar in age, socioeconomic class, and years of education (≥12 years). All participants completed a questionnaire (assessing personal, occupational, and medical histories), general and neurological clinical examination, neurobehavioural test battery (including tests for verbal abstraction, problem solving, attention, memory, and visuomotor speed), personality assessment, and serological analysis for serum acetylcholinesterase. Results: After correcting for confounders of age and education, the exposed participants exhibited significantly lower performance than controls on six neurobehavioural tests (Similarities, Digit Symbol, Trailmaking part A and B, Letter Cancellation, Digit Span, and Benton Visual Retention). A longer duration of work with pesticides was associated with lower performance on most neurobehavioural tests after adjusting for multiple comparisons. Although serum acetylcholinesterase was significantly lower in the exposed than the control participants, it was not significantly correlated with either neurobehavioural performance or neurological abnormalities. Conclusions: Occupational exposure to OP pesticides was associated with deficits in a wider array of neurobehavioural functions than previously reported, perhaps because of higher exposure in this population. Moderate chronic OP exposure may not only affect visuomotor speed as reported previously, but also verbal abstraction, attention, and memory.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalOccupational and Environmental Medicine
Volume60
Issue number4
DOIs
StatePublished - Apr 1 2003

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Pesticides
pesticide
Acetylcholinesterase
serum
education
Personality Assessment
Education
Egypt
Neurologic Examination
occupational exposure
Occupational Exposure
abnormality
Serum
Occupations
occupation
cotton
crop
effect
test
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Environmental Science(all)

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Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. / Farahat, T. M.; Abdelrasoul, G. M.; Amr, M. M.; Shebl, M. M.; Farahat, F. M.; Anger, Wyndham.

In: Occupational and Environmental Medicine, Vol. 60, No. 4, 01.04.2003, p. 279-286.

Research output: Contribution to journalArticle

Farahat, T. M. ; Abdelrasoul, G. M. ; Amr, M. M. ; Shebl, M. M. ; Farahat, F. M. ; Anger, Wyndham. / Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. In: Occupational and Environmental Medicine. 2003 ; Vol. 60, No. 4. pp. 279-286.
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