Neural correlates of verbal learning in adolescent alcohol and marijuana users

Alecia Dager Schweinsburg, Brian C. Schweinsburg, Bonnie Nagel, Lisa T. Eyler, Susan F. Tapert

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Aims Alcohol and marijuana are the most widely used intoxicants among adolescents, yet their potential unique and interactive influences on the developing brain are not well established. Brain regions subserving learning and memory undergo continued maturation during adolescence, and may be particularly susceptible to substance-related neurotoxic damage. In this study, we characterize brain response during verbal learning among adolescent users of alcohol and marijuana. Design Participants performed a verbal paired associates encoding task during functional magnetic resonance imaging (fMRI) scanning. Setting Adolescent subjects were recruited from local public schools and imaged at a university-based fMRI center. Participants Participants were 74 16-18-year-olds, divided into four groups: (i) 22 controls with limited alcohol and marijuana experience, (ii) 16 binge drinkers, (iii) eight marijuana users and (iv) 28 binge drinking marijuana users. Measurements Diagnostic interview ensured that all teens were free from neurological or psychiatric disorders; urine toxicology and breathalyzer verified abstinence for 22-28 days before scanning; a verbal paired associates task was administered during fMRI. Findings Groups demonstrated no differences in performance on the verbal encoding task, yet exhibited different brain response patterns. A main effect of drinking pointed to decreased inferior frontal but increased dorsal frontal and parietal fMRI response among binge drinkers (corrected P

Original languageEnglish (US)
Pages (from-to)564-573
Number of pages10
JournalAddiction
Volume106
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Verbal Learning
Cannabis
Alcohols
Magnetic Resonance Imaging
Brain
Binge Drinking
Toxicology
Drinking
Psychiatry
Learning
Urine
Interviews

Keywords

  • Adolescence
  • Alcohol
  • Binge drinking
  • Cannabis
  • Functional magnetic resonance imaging
  • Verbal learning

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Schweinsburg, A. D., Schweinsburg, B. C., Nagel, B., Eyler, L. T., & Tapert, S. F. (2011). Neural correlates of verbal learning in adolescent alcohol and marijuana users. Addiction, 106(3), 564-573. https://doi.org/10.1111/j.1360-0443.2010.03197.x

Neural correlates of verbal learning in adolescent alcohol and marijuana users. / Schweinsburg, Alecia Dager; Schweinsburg, Brian C.; Nagel, Bonnie; Eyler, Lisa T.; Tapert, Susan F.

In: Addiction, Vol. 106, No. 3, 03.2011, p. 564-573.

Research output: Contribution to journalArticle

Schweinsburg, AD, Schweinsburg, BC, Nagel, B, Eyler, LT & Tapert, SF 2011, 'Neural correlates of verbal learning in adolescent alcohol and marijuana users', Addiction, vol. 106, no. 3, pp. 564-573. https://doi.org/10.1111/j.1360-0443.2010.03197.x
Schweinsburg, Alecia Dager ; Schweinsburg, Brian C. ; Nagel, Bonnie ; Eyler, Lisa T. ; Tapert, Susan F. / Neural correlates of verbal learning in adolescent alcohol and marijuana users. In: Addiction. 2011 ; Vol. 106, No. 3. pp. 564-573.
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