Neonatal immunology

Robert Schelonka, A. J. Infante

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The neonate, whether premature or of normal gestational age, is a unique host from an immunologic perspective. Many components of the immune system function less well in neonates compared with adults, giving rise to the concept of an 'immunodeficiency of immaturity.' The adaptive significance of these alterations for neonatal survival remains obscure. This review highlights some of the most prominent quantitative and qualitative differences between neonatal and adult immune systems. From a clinical standpoint, the most important differences appear to be (1) reduction in the available bone marrow reserve of granulocyte precursors, (2) reduction in serum complement activity, (3) decreased ability to produce antibodies against bacterial polysaccharide antigens, and (4) increased percentage of T lymphocytes bearing an antigenically 'naive' cell surface phenotype and a correspondingly naive functional program.

Original languageEnglish (US)
Pages (from-to)2-14
Number of pages13
JournalSeminars in Perinatology
Volume22
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

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Allergy and Immunology
Immune System
Bacterial Polysaccharides
Bacterial Antigens
Complement C3
Granulocytes
Gestational Age
Bone Marrow
T-Lymphocytes
Phenotype
Antibodies
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Neonatal immunology. / Schelonka, Robert; Infante, A. J.

In: Seminars in Perinatology, Vol. 22, No. 1, 1998, p. 2-14.

Research output: Contribution to journalArticle

Schelonka, Robert ; Infante, A. J. / Neonatal immunology. In: Seminars in Perinatology. 1998 ; Vol. 22, No. 1. pp. 2-14.
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