Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference

Christopher Cunningham, Shelly D. Dickinson, Dobrina M. Okorn

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Mice (DBA/2J) received a Pavlovian procedure in which a distinctive floor stimulus was paired 4 times with ethanol (2 g/kg). A different floor stimulus was paired with saline. Naloxone (0.0, 1.5, or 10.0 mg/kg, intraperitoneal) given before each ethanol trial did not interfere with acquisition of conditioned preference, although naloxone alone produced conditioned aversion. When naloxone (0.0, 0.15, 1.5, 3.0, or 10.0 mg/kg) was given for the first time during testing, mice showed conditioned preference during the first 10 min. However, preference subsequently decreased dose-dependently over time. Control studies eliminated alternative interpretations based on pharmacokinetics or presence of an aversive state. The overall pattern of results suggests that naloxone facilitated extinction of conditioned place preference and supports the hypothesis that ethanol-induced conditioned reinforcement is mediated by the endogenous opioid system.

Original languageEnglish (US)
Pages (from-to)330-343
Number of pages14
JournalExperimental and Clinical Psychopharmacology
Volume3
Issue number4
StatePublished - Nov 1995

Fingerprint

Naloxone
Ethanol
Inbred DBA Mouse
Opioid Analgesics
Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Experimental and Cognitive Psychology

Cite this

Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference. / Cunningham, Christopher; Dickinson, Shelly D.; Okorn, Dobrina M.

In: Experimental and Clinical Psychopharmacology, Vol. 3, No. 4, 11.1995, p. 330-343.

Research output: Contribution to journalArticle

@article{25d80309552346e6a0b82ddab951c549,
title = "Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference",
abstract = "Mice (DBA/2J) received a Pavlovian procedure in which a distinctive floor stimulus was paired 4 times with ethanol (2 g/kg). A different floor stimulus was paired with saline. Naloxone (0.0, 1.5, or 10.0 mg/kg, intraperitoneal) given before each ethanol trial did not interfere with acquisition of conditioned preference, although naloxone alone produced conditioned aversion. When naloxone (0.0, 0.15, 1.5, 3.0, or 10.0 mg/kg) was given for the first time during testing, mice showed conditioned preference during the first 10 min. However, preference subsequently decreased dose-dependently over time. Control studies eliminated alternative interpretations based on pharmacokinetics or presence of an aversive state. The overall pattern of results suggests that naloxone facilitated extinction of conditioned place preference and supports the hypothesis that ethanol-induced conditioned reinforcement is mediated by the endogenous opioid system.",
author = "Christopher Cunningham and Dickinson, {Shelly D.} and Okorn, {Dobrina M.}",
year = "1995",
month = "11",
language = "English (US)",
volume = "3",
pages = "330--343",
journal = "Experimental and Clinical Psychopharmacology",
issn = "1064-1297",
publisher = "American Psychological Association Inc.",
number = "4",

}

TY - JOUR

T1 - Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference

AU - Cunningham, Christopher

AU - Dickinson, Shelly D.

AU - Okorn, Dobrina M.

PY - 1995/11

Y1 - 1995/11

N2 - Mice (DBA/2J) received a Pavlovian procedure in which a distinctive floor stimulus was paired 4 times with ethanol (2 g/kg). A different floor stimulus was paired with saline. Naloxone (0.0, 1.5, or 10.0 mg/kg, intraperitoneal) given before each ethanol trial did not interfere with acquisition of conditioned preference, although naloxone alone produced conditioned aversion. When naloxone (0.0, 0.15, 1.5, 3.0, or 10.0 mg/kg) was given for the first time during testing, mice showed conditioned preference during the first 10 min. However, preference subsequently decreased dose-dependently over time. Control studies eliminated alternative interpretations based on pharmacokinetics or presence of an aversive state. The overall pattern of results suggests that naloxone facilitated extinction of conditioned place preference and supports the hypothesis that ethanol-induced conditioned reinforcement is mediated by the endogenous opioid system.

AB - Mice (DBA/2J) received a Pavlovian procedure in which a distinctive floor stimulus was paired 4 times with ethanol (2 g/kg). A different floor stimulus was paired with saline. Naloxone (0.0, 1.5, or 10.0 mg/kg, intraperitoneal) given before each ethanol trial did not interfere with acquisition of conditioned preference, although naloxone alone produced conditioned aversion. When naloxone (0.0, 0.15, 1.5, 3.0, or 10.0 mg/kg) was given for the first time during testing, mice showed conditioned preference during the first 10 min. However, preference subsequently decreased dose-dependently over time. Control studies eliminated alternative interpretations based on pharmacokinetics or presence of an aversive state. The overall pattern of results suggests that naloxone facilitated extinction of conditioned place preference and supports the hypothesis that ethanol-induced conditioned reinforcement is mediated by the endogenous opioid system.

UR - http://www.scopus.com/inward/record.url?scp=0028879203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028879203&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 330

EP - 343

JO - Experimental and Clinical Psychopharmacology

JF - Experimental and Clinical Psychopharmacology

SN - 1064-1297

IS - 4

ER -