Nafion-coated electrodes with high selectivity for CNS electrochemistry

Greg A. Gerhardt, Arvin F. Oke, Geza Nagy, Bita Moghaddam, Ralph N. Adams

Research output: Contribution to journalArticlepeer-review

554 Scopus citations

Abstract

A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalBrain research
Volume290
Issue number2
DOIs
StatePublished - Jan 9 1984

Keywords

  • Nafion-coated electrodes
  • in vivo electrochemistry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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