Myocardial tissue remodeling in adolescent obesity.

Ravi V. Shah, Siddique A. Abbasi, Tomas G. Neilan, Edward Hulten, Otavio Coelho-Filho, Alison Hoppin, Lynne Levitsky, Sarah de Ferranti, Erinn T. Rhodes, Avram Traum, Elizabeth Goodman, Henry Feng, Bobak Heydari, William Harris, Daniel M. Hoefner, Joseph P. McConnell, Ravi Seethamraju, Carsten Rickers, Raymond Y. Kwong, Michael Jerosch-Herold

Research output: Contribution to journalArticle

27 Scopus citations


Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue-level markers within the myocardium that precede organ-level alterations have not been described. We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size-adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P

Original languageEnglish (US)
JournalJournal of the American Heart Association
Issue number4
Publication statusPublished - Aug 2013
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Shah, R. V., Abbasi, S. A., Neilan, T. G., Hulten, E., Coelho-Filho, O., Hoppin, A., ... Jerosch-Herold, M. (2013). Myocardial tissue remodeling in adolescent obesity. Journal of the American Heart Association, 2(4).