Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene

Stephen M. Schwartz, David S. Siscovick, M. Rene Malinow, Frits R. Rosendaal, R. Kevin Beverly, David Hess, Bruce M. Psaty, W. T. Longstreth, Thomas D. Koepsell, T. E. Raghunathan, Pieter H. Reitsma

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    Abstract

    Background: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR). Methods and Results: In-person interviews and nonfasting blood samples were obtained from 79 women 12 concentrations between case patients and control subjects (346.8±188.4 versus 349.7±132.4 pmol/L, P=.90). After adjusting for cardiovascular risk factors, we found that women with tHCY ≤15.6 μmol/L were at approximately twice the risk of MI as women with tHCY 12 concentration. Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. Ten percent of case patients were homozygous for the T677 allele, and there was no association of homozygosity for T677 with MI risk (OR, 0.90; 95% CI, 0.31 to 2.29). Conclusions: These data support the hypothesis that elevated plasma tHCY and low plasma folate are risk factors for MI among young women. Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.

    Original languageEnglish (US)
    Pages (from-to)412-417
    Number of pages6
    JournalCirculation
    Volume96
    Issue number2
    StatePublished - Jul 15 1997

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    Methylenetetrahydrofolate Reductase (NADPH2)
    Homocysteine
    Folic Acid
    Myocardial Infarction
    Genes
    Alleles
    Thymine
    Cytosine
    Vitamin B 12
    Population
    Genotype
    Interviews

    Keywords

    • Folate
    • Genetics
    • Homocysteine
    • Myocardial infarction
    • Women

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine

    Cite this

    Schwartz, S. M., Siscovick, D. S., Malinow, M. R., Rosendaal, F. R., Beverly, R. K., Hess, D., ... Reitsma, P. H. (1997). Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation, 96(2), 412-417.

    Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. / Schwartz, Stephen M.; Siscovick, David S.; Malinow, M. Rene; Rosendaal, Frits R.; Beverly, R. Kevin; Hess, David; Psaty, Bruce M.; Longstreth, W. T.; Koepsell, Thomas D.; Raghunathan, T. E.; Reitsma, Pieter H.

    In: Circulation, Vol. 96, No. 2, 15.07.1997, p. 412-417.

    Research output: Contribution to journalArticle

    Schwartz, SM, Siscovick, DS, Malinow, MR, Rosendaal, FR, Beverly, RK, Hess, D, Psaty, BM, Longstreth, WT, Koepsell, TD, Raghunathan, TE & Reitsma, PH 1997, 'Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene', Circulation, vol. 96, no. 2, pp. 412-417.
    Schwartz, Stephen M. ; Siscovick, David S. ; Malinow, M. Rene ; Rosendaal, Frits R. ; Beverly, R. Kevin ; Hess, David ; Psaty, Bruce M. ; Longstreth, W. T. ; Koepsell, Thomas D. ; Raghunathan, T. E. ; Reitsma, Pieter H. / Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. In: Circulation. 1997 ; Vol. 96, No. 2. pp. 412-417.
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    abstract = "Background: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR). Methods and Results: In-person interviews and nonfasting blood samples were obtained from 79 women 12 concentrations between case patients and control subjects (346.8±188.4 versus 349.7±132.4 pmol/L, P=.90). After adjusting for cardiovascular risk factors, we found that women with tHCY ≤15.6 μmol/L were at approximately twice the risk of MI as women with tHCY 12 concentration. Among control subjects, 12.7{\%} were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. Ten percent of case patients were homozygous for the T677 allele, and there was no association of homozygosity for T677 with MI risk (OR, 0.90; 95{\%} CI, 0.31 to 2.29). Conclusions: These data support the hypothesis that elevated plasma tHCY and low plasma folate are risk factors for MI among young women. Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.",
    keywords = "Folate, Genetics, Homocysteine, Myocardial infarction, Women",
    author = "Schwartz, {Stephen M.} and Siscovick, {David S.} and Malinow, {M. Rene} and Rosendaal, {Frits R.} and Beverly, {R. Kevin} and David Hess and Psaty, {Bruce M.} and Longstreth, {W. T.} and Koepsell, {Thomas D.} and Raghunathan, {T. E.} and Reitsma, {Pieter H.}",
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    T1 - Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene

    AU - Schwartz, Stephen M.

    AU - Siscovick, David S.

    AU - Malinow, M. Rene

    AU - Rosendaal, Frits R.

    AU - Beverly, R. Kevin

    AU - Hess, David

    AU - Psaty, Bruce M.

    AU - Longstreth, W. T.

    AU - Koepsell, Thomas D.

    AU - Raghunathan, T. E.

    AU - Reitsma, Pieter H.

    PY - 1997/7/15

    Y1 - 1997/7/15

    N2 - Background: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR). Methods and Results: In-person interviews and nonfasting blood samples were obtained from 79 women 12 concentrations between case patients and control subjects (346.8±188.4 versus 349.7±132.4 pmol/L, P=.90). After adjusting for cardiovascular risk factors, we found that women with tHCY ≤15.6 μmol/L were at approximately twice the risk of MI as women with tHCY 12 concentration. Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. Ten percent of case patients were homozygous for the T677 allele, and there was no association of homozygosity for T677 with MI risk (OR, 0.90; 95% CI, 0.31 to 2.29). Conclusions: These data support the hypothesis that elevated plasma tHCY and low plasma folate are risk factors for MI among young women. Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.

    AB - Background: In a population-based study, we examined the relationship between the risk of myocardial infarction (MI) among young women and plasma total homocysteine (tHCY), folate, vitamin B12, and a common cytosine (C) to thymine (T) polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR). Methods and Results: In-person interviews and nonfasting blood samples were obtained from 79 women 12 concentrations between case patients and control subjects (346.8±188.4 versus 349.7±132.4 pmol/L, P=.90). After adjusting for cardiovascular risk factors, we found that women with tHCY ≤15.6 μmol/L were at approximately twice the risk of MI as women with tHCY 12 concentration. Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. Ten percent of case patients were homozygous for the T677 allele, and there was no association of homozygosity for T677 with MI risk (OR, 0.90; 95% CI, 0.31 to 2.29). Conclusions: These data support the hypothesis that elevated plasma tHCY and low plasma folate are risk factors for MI among young women. Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.

    KW - Folate

    KW - Genetics

    KW - Homocysteine

    KW - Myocardial infarction

    KW - Women

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