Myocardial Depression: The Effect of Ca++ and Calcium Flux During Sepsis

Marc A. Levison, Tanny C. Tsao, Donald Trunkey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous studies from this laboratory described myocardial depression in an arterially perfused rabbit interventricular septum following perfusion with acute septic plasma. Calcium Is critical for maintenance of cardiac contractility on a beat-to-beat basis. We have investigated calcium flux in the septal tissue to determine whether altered calcium flux explains the impaired cardiac function during sepsis. Twenty-two rabbit septa were perfused with control and septic perfusate (cryoprecipitated plasma + RBCs) and calcium flux determined in seven experiments. Perfusate cations (Ca++, Na+, K+, and H+) were measures, tissue function and arterial pressure were monitored. Developed tension decreased 46%, acceleration of tension change fell 42%, and arterial pressure decreased 26%, all highly significant. All septa recovered after return to control perfusate. The septic perfusate Ca++ was significantly lower than control perfusate, while K+ and H+ were significantly elevated. Ion flux studies, however, could not demonstrate altered calcium flux associated with the depressed contractility.

Original languageEnglish (US)
Pages (from-to)803-808
Number of pages6
JournalArchives of Surgery
Volume119
Issue number7
DOIs
StatePublished - 1984
Externally publishedYes

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Sepsis
Calcium
Arterial Pressure
Rabbits
Cations
Perfusion
Maintenance
Ions

ASJC Scopus subject areas

  • Surgery

Cite this

Myocardial Depression : The Effect of Ca++ and Calcium Flux During Sepsis. / Levison, Marc A.; Tsao, Tanny C.; Trunkey, Donald.

In: Archives of Surgery, Vol. 119, No. 7, 1984, p. 803-808.

Research output: Contribution to journalArticle

Levison, Marc A. ; Tsao, Tanny C. ; Trunkey, Donald. / Myocardial Depression : The Effect of Ca++ and Calcium Flux During Sepsis. In: Archives of Surgery. 1984 ; Vol. 119, No. 7. pp. 803-808.
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