Myelodysplastic Syndromes: Updates and Nuances

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Myelodysplastic syndrome (MDS) is a heterogeneous, clonal stem cell disorder of the blood and marrow typically diagnosed based on the presence of persistent cytopenia(s), dysplastic cells, and genetic markers. Common issues that arise in the clinical management include difficulty confirming MDS diagnosis, lack of a standard approach with novel agents in MDS, and few prospective long-term, randomized controlled MDS clinical studies to guide allogeneic blood and marrow transplant. With the recent genetic characterization of MDS, certain aspects of these issues will be better addressed by integrating genetic data into clinical study design and clinical practice.

Original languageEnglish (US)
Pages (from-to)333-350
Number of pages18
JournalMedical Clinics of North America
Volume101
Issue number2
DOIs
StatePublished - Mar 1 2017

Keywords

  • Anemia
  • Azacitidine
  • Blood and marrow transplant
  • Myelodysplastic syndrome
  • Therapy-related myelodysplastic syndrome

ASJC Scopus subject areas

  • Medicine(all)

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