Myelin changes in the rats CNS following intraventricular injection of serum

G. Konat, N. H. Diemer, Halina Offner

Research output: Contribution to journalArticle

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Abstract

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalExperientia
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 1986
Externally publishedYes

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Keywords

  • CNS
  • demyelination
  • dissociated myelin
  • intrathecal injection
  • multiple sclerosis
  • Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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