Myelin changes in the rats CNS following intraventricular injection of serum

G. Konat, N. H. Diemer, H. Offner

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalExperientia
Volume42
Issue number1
DOIs
StatePublished - Jan 1 1986

Keywords

  • CNS
  • Serum
  • demyelination
  • dissociated myelin
  • intrathecal injection
  • multiple sclerosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Myelin changes in the rats CNS following intraventricular injection of serum'. Together they form a unique fingerprint.

  • Cite this