Myelin changes in the rats CNS following intraventricular injection of serum

G. Konat, N. H. Diemer, Halina Offner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalExperientia
Volume42
Issue number1
DOIs
StatePublished - Jan 1986
Externally publishedYes

Fingerprint

Intraventricular Injections
Myelin Sheath
Rats
Tissue
Recovery
Level control
Serum
Membranes

Keywords

  • CNS
  • demyelination
  • dissociated myelin
  • intrathecal injection
  • multiple sclerosis
  • Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Myelin changes in the rats CNS following intraventricular injection of serum. / Konat, G.; Diemer, N. H.; Offner, Halina.

In: Experientia, Vol. 42, No. 1, 01.1986, p. 37-39.

Research output: Contribution to journalArticle

Konat, G. ; Diemer, N. H. ; Offner, Halina. / Myelin changes in the rats CNS following intraventricular injection of serum. In: Experientia. 1986 ; Vol. 42, No. 1. pp. 37-39.
@article{cfcefce323df497ca7d65d6d4990c7b1,
title = "Myelin changes in the rats CNS following intraventricular injection of serum",
abstract = "Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.",
keywords = "CNS, demyelination, dissociated myelin, intrathecal injection, multiple sclerosis, Serum",
author = "G. Konat and Diemer, {N. H.} and Halina Offner",
year = "1986",
month = "1",
doi = "10.1007/BF01975883",
language = "English (US)",
volume = "42",
pages = "37--39",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "1",

}

TY - JOUR

T1 - Myelin changes in the rats CNS following intraventricular injection of serum

AU - Konat, G.

AU - Diemer, N. H.

AU - Offner, Halina

PY - 1986/1

Y1 - 1986/1

N2 - Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

AB - Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

KW - CNS

KW - demyelination

KW - dissociated myelin

KW - intrathecal injection

KW - multiple sclerosis

KW - Serum

UR - http://www.scopus.com/inward/record.url?scp=0022599322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022599322&partnerID=8YFLogxK

U2 - 10.1007/BF01975883

DO - 10.1007/BF01975883

M3 - Article

C2 - 3943596

AN - SCOPUS:0022599322

VL - 42

SP - 37

EP - 39

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 1

ER -