Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15

Nicholas J. Wang, Alexander S. Parokonny, Karen N. Thatcher, Jennette Driscoll, Barbara M. Malone, Naghmeh Dorrani, Marian Sigman, Janine M. LaSalle, N. Carolyn Schanen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Maternally-derived duplications that include the imprinted region on the proximal long arm of chromosome 15 underlie a complex neurobehavioral disorder characterized by cognitive impairment, seizures and a substantial risk for autism spectrum disorders1. The duplications most often take the form of a supernumerary pseudodicentric derivative chromosome 15 [der(15)] that has been called inverted duplication 15 or isodicentric 15 [idic(15)], although interstitial rearrangements also occur. Similar to the deletions found in most cases of Angelman and Prader Willi syndrome, the duplications appear to be mediated by unequal homologous recombination involving low copy repeats (LCR) that are found clustered in the region. Five recurrent breakpoints have been described in most cases of segmental aneuploidy of chromosome 15q11-q13 and previous studies have shown that most idic(15) chromosomes arise through BP3:BP3 or BP4:BP5 recombination events. Results: Here we describe four duplication chromosomes that show evidence of atypical recombination events that involve regions outside the common breakpoints. Additionally, in one patient with a mosaic complex der(15), we examined homologous pairing of chromosome 15q11-q13 alleles by FISH in a region of frontal cortex, which identified mosaicism in this tissue and also demonstrated pairing of the signals from the der(15) and the normal homologues. Conclusion: Involvement of atypical BP in the generation of idic(15) chromosomes can lead to considerable structural heterogeneity.

Original languageEnglish (US)
Article number2
JournalBMC Genetics
Volume9
DOIs
StatePublished - Jan 4 2008
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 15
Genetic Recombination
Genomic Segmental Duplications
Chromosome Duplication
Chromosome Pairing
Prader-Willi Syndrome
Mosaicism
Homologous Recombination
Frontal Lobe
Aneuploidy
Autistic Disorder
Seizures
Chromosomes
Alleles
Isodicentric Chromosome 15 Syndrome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Wang, N. J., Parokonny, A. S., Thatcher, K. N., Driscoll, J., Malone, B. M., Dorrani, N., ... Schanen, N. C. (2008). Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genetics, 9, [2]. https://doi.org/10.1186/1471-2156-9-2

Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. / Wang, Nicholas J.; Parokonny, Alexander S.; Thatcher, Karen N.; Driscoll, Jennette; Malone, Barbara M.; Dorrani, Naghmeh; Sigman, Marian; LaSalle, Janine M.; Schanen, N. Carolyn.

In: BMC Genetics, Vol. 9, 2, 04.01.2008.

Research output: Contribution to journalArticle

Wang, NJ, Parokonny, AS, Thatcher, KN, Driscoll, J, Malone, BM, Dorrani, N, Sigman, M, LaSalle, JM & Schanen, NC 2008, 'Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15', BMC Genetics, vol. 9, 2. https://doi.org/10.1186/1471-2156-9-2
Wang NJ, Parokonny AS, Thatcher KN, Driscoll J, Malone BM, Dorrani N et al. Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genetics. 2008 Jan 4;9. 2. https://doi.org/10.1186/1471-2156-9-2
Wang, Nicholas J. ; Parokonny, Alexander S. ; Thatcher, Karen N. ; Driscoll, Jennette ; Malone, Barbara M. ; Dorrani, Naghmeh ; Sigman, Marian ; LaSalle, Janine M. ; Schanen, N. Carolyn. / Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. In: BMC Genetics. 2008 ; Vol. 9.
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