Multiple conductance change associated with the slow excitatory potential in mammalian sympathetic neurons

Z. G. Jiang, N. J. Dun

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

When the membrane potential was manually clamped, the non-cholinergic excitatory potential was associated with either a sustained increase, an initial decrease followed by a prolonged increase or no apparent change in neuronal input resistance. In the majority of neurons studied, the amplitude of non-cholinergic depolarization was augmented upon conditioning hyperpolarization, whereas it was attenuated in a low Na solution. The results are consistent with the suggestion that the non-cholinergic depolarization may be generated by a change of multiple conductances that may include GNa activation and GK inactivation.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalBrain research
Volume229
Issue number1
DOIs
StatePublished - Dec 14 1981

Keywords

  • G activation
  • G inactivation
  • non-cholinergic excitatory potential
  • sympathetic neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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