Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance

David Seifer, David T. MacLaughlin

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Objective: To examine Mullerian Inhibiting Substance (MIS) as an emerging diagnostic marker of ovarian function. Design: Medline review of published studies pertaining to the role of MIS in assessing ovarian aging, predicting response to ovulation induction in preparation for in vitro fertilization, assessing risk of developing ovarian hyperstimulation (OHSS) before ovulation induction, and diagnosis of polycystic ovarian disease (PCOS). Result(s): The majority of published studies to date support a role for MIS as a marker of ovarian reserve. Specific cut-off values are dependent upon the particular assay used. Mullerian Inhibiting Substance may offer value in assessing risk of OHSS and diagnosis of PCOS. Conclusion(s): Potential advantages of MIS compared with other conventional markers of ovarian reserve include: 1) MIS is the earliest marker to change with age; 2) it has the least intercycle variability; 3) it has the least intracycle variability; and 4) it may be informative if randomly obtained during the cycle. Widespread clinical use of MIS may await the availability of an international standard for MIS so that results using different assays may be reliably compared.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalFertility and Sterility
Volume88
Issue number3
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Anti-Mullerian Hormone
Intercellular Signaling Peptides and Proteins
Ovarian Diseases
Ovulation Induction
Fertilization in Vitro

Keywords

  • AMH
  • IVF
  • MIS
  • OHSS
  • ovarian aging
  • ovarian reserve
  • PCOS

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. / Seifer, David; MacLaughlin, David T.

In: Fertility and Sterility, Vol. 88, No. 3, 09.2007, p. 539-546.

Research output: Contribution to journalArticle

Seifer, David ; MacLaughlin, David T. / Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. In: Fertility and Sterility. 2007 ; Vol. 88, No. 3. pp. 539-546.
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