MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial: The NIA plaque study

Christopher Sibley, Andrea L. Vavere, Ilan Gottlieb, Christopher Cox, Matthew Matheson, Amy Spooner, Gustavo Godoy, Veronica Fernandes, Bruce A. Wasserman, David A. Bluemke, Joao A C Lima

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective To evaluate the benefit of niacin in addition to statin therapy on plaque regression among older individuals with established atherosclerosis. Design Randomised, controlled, double-blind clinical trial. Setting University outpatient center. Patients 145 patients older than 65 years, half of them older than 75 years of age, with established atherosclerosis were enrolled. Interventions Participants received either extended release niacin (1500 mg daily) or placebo in addition to statin therapy to reach their National Cholesterol Education Program-defined low density lipoprotein (LDL) cholesterol target. Main Outcome Measures The primary endpoint was reduction in the wall volume of the internal carotid artery (ICA) measured by MRI. Results After 18 months, high density lipoprotein cholesterol was higher with statins plus niacin compared with statins alone (1.6±0.4 vs 1.4±0.4 mmol/L p

Original languageEnglish (US)
Pages (from-to)1675-1680
Number of pages6
JournalHeart
Volume99
Issue number22
DOIs
StatePublished - Nov 2013
Externally publishedYes

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Carotid Artery Diseases
Niacin
Randomized Controlled Trials
Atherosclerosis
Internal Carotid Artery
LDL Cholesterol
HDL Cholesterol
Outpatients
Cholesterol
Placebos
Outcome Assessment (Health Care)
Clinical Trials
Education
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial : The NIA plaque study. / Sibley, Christopher; Vavere, Andrea L.; Gottlieb, Ilan; Cox, Christopher; Matheson, Matthew; Spooner, Amy; Godoy, Gustavo; Fernandes, Veronica; Wasserman, Bruce A.; Bluemke, David A.; Lima, Joao A C.

In: Heart, Vol. 99, No. 22, 11.2013, p. 1675-1680.

Research output: Contribution to journalArticle

Sibley, C, Vavere, AL, Gottlieb, I, Cox, C, Matheson, M, Spooner, A, Godoy, G, Fernandes, V, Wasserman, BA, Bluemke, DA & Lima, JAC 2013, 'MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial: The NIA plaque study', Heart, vol. 99, no. 22, pp. 1675-1680. https://doi.org/10.1136/heartjnl-2013-303926
Sibley, Christopher ; Vavere, Andrea L. ; Gottlieb, Ilan ; Cox, Christopher ; Matheson, Matthew ; Spooner, Amy ; Godoy, Gustavo ; Fernandes, Veronica ; Wasserman, Bruce A. ; Bluemke, David A. ; Lima, Joao A C. / MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial : The NIA plaque study. In: Heart. 2013 ; Vol. 99, No. 22. pp. 1675-1680.
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AU - Cox, Christopher

AU - Matheson, Matthew

AU - Spooner, Amy

AU - Godoy, Gustavo

AU - Fernandes, Veronica

AU - Wasserman, Bruce A.

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AU - Lima, Joao A C

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