TY - JOUR
T1 - MR1-dependent antigen presentation
AU - Karamooz, Elham
AU - Harriff, Melanie J.
AU - Lewinsohn, David M.
N1 - Publisher Copyright:
© 2017
PY - 2018/12
Y1 - 2018/12
N2 - MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, –B, and –C, little MR1 is on the cell surface. Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as those found in the riboflavin biosynthesis pathway. Since mammals do not synthesize riboflavin, MR1 can serve as a sensor of the microbial metabolome and could be key to the early detection of intracellular infection. This review will summarize the current understanding of MR1-dependent antigen presentation.
AB - MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, –B, and –C, little MR1 is on the cell surface. Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as those found in the riboflavin biosynthesis pathway. Since mammals do not synthesize riboflavin, MR1 can serve as a sensor of the microbial metabolome and could be key to the early detection of intracellular infection. This review will summarize the current understanding of MR1-dependent antigen presentation.
KW - Antigen presentation
KW - MR1
KW - Mucosal associated invariant T cells
UR - http://www.scopus.com/inward/record.url?scp=85056594252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056594252&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2017.11.028
DO - 10.1016/j.semcdb.2017.11.028
M3 - Review article
C2 - 30449535
AN - SCOPUS:85056594252
SN - 1084-9521
VL - 84
SP - 58
EP - 64
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -