MR1-dependent antigen presentation

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, –B, and –C, little MR1 is on the cell surface. Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as those found in the riboflavin biosynthesis pathway. Since mammals do not synthesize riboflavin, MR1 can serve as a sensor of the microbial metabolome and could be key to the early detection of intracellular infection. This review will summarize the current understanding of MR1-dependent antigen presentation.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume84
DOIs
StatePublished - Dec 1 2018

Fingerprint

Riboflavin
Antigen Presentation
Mammals
HLA-C Antigens
HLA-A Antigens
HLA-B Antigens
Metabolome
Endoplasmic Reticulum
Ligands
T-Lymphocytes
Antigens
Infection

Keywords

  • Antigen presentation
  • MR1
  • Mucosal associated invariant T cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

MR1-dependent antigen presentation. / Karamooz, Elham; Harriff, Melanie; Lewinsohn, David.

In: Seminars in Cell and Developmental Biology, Vol. 84, 01.12.2018, p. 58-64.

Research output: Contribution to journalReview article

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