Movements of vesicles on microtubules.

M. P. Sheetz, R. Vale, Bruce Schnapp, T. Schroer, T. Reese

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Many cytoplasmic vesicles are observed to move along microtubules. Often, bidirectional movement of particles is observed on a single microtubule. We have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus and minus ends of microtubules, respectively. Observations of vesicle movements show that vesicles have a defined direction of movement and that vesicles copurify with a kinesin motor activity. Current evidence suggests the hypothesis that kinesin and the retrograde motors power vesicle movements in vivo by attachment to the appropriate vesicle.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume493
StatePublished - 1987
Externally publishedYes

Fingerprint

Kinesin
Microtubules
Cytoplasmic Vesicles
Latex
Microspheres
Motor Activity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sheetz, M. P., Vale, R., Schnapp, B., Schroer, T., & Reese, T. (1987). Movements of vesicles on microtubules. Annals of the New York Academy of Sciences, 493, 409-416.

Movements of vesicles on microtubules. / Sheetz, M. P.; Vale, R.; Schnapp, Bruce; Schroer, T.; Reese, T.

In: Annals of the New York Academy of Sciences, Vol. 493, 1987, p. 409-416.

Research output: Contribution to journalArticle

Sheetz, MP, Vale, R, Schnapp, B, Schroer, T & Reese, T 1987, 'Movements of vesicles on microtubules.', Annals of the New York Academy of Sciences, vol. 493, pp. 409-416.
Sheetz, M. P. ; Vale, R. ; Schnapp, Bruce ; Schroer, T. ; Reese, T. / Movements of vesicles on microtubules. In: Annals of the New York Academy of Sciences. 1987 ; Vol. 493. pp. 409-416.
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