Mouse behavioural analysis in systems biology

Peter Van Meer, Jacob Raber

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Molecular techniques allowing in vivo modulation of gene expression have provided unique opportunities and challenges for behavioural studies aimed at understanding the function of particular genes or biological systems under physiological or pathological conditions. Although various animal models are available, the laboratory mouse (Mus musculus) has unique features and is therefore a preferred animal model. The mouse shares a remarkable genetic resemblance and aspects of behaviour with humans. In this review, first we describe common mouse models for behavioural analyses. As both genetic and environmental factors influence behavioural performance and need to be carefully evaluated in behavioural experiments, considerations for designing and interpretations of these experiments are subsequently discussed. Finally, common behavioural tests used to assess brain function are reviewed, and it is illustrated how behavioural tests are used to increase our understanding of the role of histaminergic neurotransmission in brain function.

Original languageEnglish (US)
Pages (from-to)593-610
Number of pages18
JournalBiochemical Journal
Volume389
Issue number3
DOIs
StatePublished - Aug 1 2005

Keywords

  • Apolipoprotein E
  • Behavioural phenotyping
  • Behavioural testing
  • Histamine
  • Histamine receptor
  • Mouse model
  • Transgenic gene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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