Motor and mental aspects of acute extrapyramidal syndromes.

Daniel Casey

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Acute extrapyramidal syndromes (EPS) are one of the major limitations to effective neuroleptic treatment. These disorders have both motor (objective) and mental (subjective) aspects, which must be considered in any evaluation and differential diagnosis of treatment-related side effects. The disorders of akathisia, acute dystonia and parkinsonism have unique features that are best understood in the context of a careful assessment of patient characteristics, drug factors and temporal aspects. Though acute EPS are commonly explained on the basis of dopamine D2 receptor antagonism, data from several lines of study raise important questions about this hypothesis. The roles of receptor subtype specificity, brain region selectivity and ratios of different receptor subtype antagonism are discussed. New and novel antipsychotic drugs with low rates of EPS are important clinical advancements that will increase patients' ability to participate in therapy and rehabilitation and thus improve their quality of life.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalActa Psychiatrica Scandinavica, Supplement
Volume380
StatePublished - 1994

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Antipsychotic Agents
Psychomotor Agitation
Aptitude
Dopamine D2 Receptors
Dystonia
Parkinsonian Disorders
Differential Diagnosis
Therapeutics
Rehabilitation
Quality of Life
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Motor and mental aspects of acute extrapyramidal syndromes. / Casey, Daniel.

In: Acta Psychiatrica Scandinavica, Supplement, Vol. 380, 1994, p. 14-20.

Research output: Contribution to journalArticle

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