Mortality risk in older men associated with changes in weight, lean mass, and fat mass

Christine Lee, Edward J. Boyko, Carrie Nielson, Marcia L. Stefanick, Douglas C. Bauer, Andrew R. Hoffman, Thuy Tien L Dam, Jodi Lapidus, Peggy Mannen Cawthon, Kristine E. Ensrud, Eric Orwoll

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Objective: To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men. Design: Longitudinal cohort study. Setting: Six U.S. clinical centers. Participants: Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline. Measurements: Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5%), loss (-5%), or stable (-5% to +5%). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality. Results: After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95% confidence interval (CI)=1.50-2.26), total lean mass loss (HR=1.78, 95% CI=1.45-2.19), and total fat mass loss (HR=1.72, 95% CI=1.34-2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95% CI=0.99-1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status (P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass (P for interaction=.04) and total lean mass (P for interaction=.09) change. Conclusion: Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalJournal of the American Geriatrics Society
Volume59
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Fats
Weights and Measures
Mortality
Confidence Intervals
Weight Loss
Body Weights and Measures
Body Weight Changes
Death Certificates
Photon Absorptiometry
Body Composition
Proportional Hazards Models
Health Status
Longitudinal Studies
Life Style
Cohort Studies
Obesity
Body Weight

Keywords

  • body composition
  • fat mass
  • lean mass
  • mortality
  • older men

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Mortality risk in older men associated with changes in weight, lean mass, and fat mass. / Lee, Christine; Boyko, Edward J.; Nielson, Carrie; Stefanick, Marcia L.; Bauer, Douglas C.; Hoffman, Andrew R.; Dam, Thuy Tien L; Lapidus, Jodi; Cawthon, Peggy Mannen; Ensrud, Kristine E.; Orwoll, Eric.

In: Journal of the American Geriatrics Society, Vol. 59, No. 2, 02.2011, p. 233-240.

Research output: Contribution to journalArticle

Lee, Christine ; Boyko, Edward J. ; Nielson, Carrie ; Stefanick, Marcia L. ; Bauer, Douglas C. ; Hoffman, Andrew R. ; Dam, Thuy Tien L ; Lapidus, Jodi ; Cawthon, Peggy Mannen ; Ensrud, Kristine E. ; Orwoll, Eric. / Mortality risk in older men associated with changes in weight, lean mass, and fat mass. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 2. pp. 233-240.
@article{9210fa4ed4704b7d841ed1f8b34332f9,
title = "Mortality risk in older men associated with changes in weight, lean mass, and fat mass",
abstract = "Objective: To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men. Design: Longitudinal cohort study. Setting: Six U.S. clinical centers. Participants: Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline. Measurements: Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5{\%}), loss (-5{\%}), or stable (-5{\%} to +5{\%}). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality. Results: After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95{\%} confidence interval (CI)=1.50-2.26), total lean mass loss (HR=1.78, 95{\%} CI=1.45-2.19), and total fat mass loss (HR=1.72, 95{\%} CI=1.34-2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95{\%} CI=0.99-1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status (P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass (P for interaction=.04) and total lean mass (P for interaction=.09) change. Conclusion: Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable.",
keywords = "body composition, fat mass, lean mass, mortality, older men",
author = "Christine Lee and Boyko, {Edward J.} and Carrie Nielson and Stefanick, {Marcia L.} and Bauer, {Douglas C.} and Hoffman, {Andrew R.} and Dam, {Thuy Tien L} and Jodi Lapidus and Cawthon, {Peggy Mannen} and Ensrud, {Kristine E.} and Eric Orwoll",
year = "2011",
month = "2",
doi = "10.1111/j.1532-5415.2010.03245.x",
language = "English (US)",
volume = "59",
pages = "233--240",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Mortality risk in older men associated with changes in weight, lean mass, and fat mass

AU - Lee, Christine

AU - Boyko, Edward J.

AU - Nielson, Carrie

AU - Stefanick, Marcia L.

AU - Bauer, Douglas C.

AU - Hoffman, Andrew R.

AU - Dam, Thuy Tien L

AU - Lapidus, Jodi

AU - Cawthon, Peggy Mannen

AU - Ensrud, Kristine E.

AU - Orwoll, Eric

PY - 2011/2

Y1 - 2011/2

N2 - Objective: To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men. Design: Longitudinal cohort study. Setting: Six U.S. clinical centers. Participants: Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline. Measurements: Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5%), loss (-5%), or stable (-5% to +5%). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality. Results: After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95% confidence interval (CI)=1.50-2.26), total lean mass loss (HR=1.78, 95% CI=1.45-2.19), and total fat mass loss (HR=1.72, 95% CI=1.34-2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95% CI=0.99-1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status (P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass (P for interaction=.04) and total lean mass (P for interaction=.09) change. Conclusion: Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable.

AB - Objective: To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men. Design: Longitudinal cohort study. Setting: Six U.S. clinical centers. Participants: Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline. Measurements: Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5%), loss (-5%), or stable (-5% to +5%). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality. Results: After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95% confidence interval (CI)=1.50-2.26), total lean mass loss (HR=1.78, 95% CI=1.45-2.19), and total fat mass loss (HR=1.72, 95% CI=1.34-2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95% CI=0.99-1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status (P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass (P for interaction=.04) and total lean mass (P for interaction=.09) change. Conclusion: Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable.

KW - body composition

KW - fat mass

KW - lean mass

KW - mortality

KW - older men

UR - http://www.scopus.com/inward/record.url?scp=79951591201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951591201&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2010.03245.x

DO - 10.1111/j.1532-5415.2010.03245.x

M3 - Article

C2 - 21288234

AN - SCOPUS:79951591201

VL - 59

SP - 233

EP - 240

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 2

ER -