Morphological changes of the dorsal contour of the corpus callosum during the first two years of life

Lauren N. Simpson, Erika J. Schneble, Elena D. Griffin, James T. Obayashi, Phillip A. Setran, Donald A. Ross, David R. Pettersson, Jeffrey M. Pollock

Research output: Contribution to journalArticle

Abstract

Background: In the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy. Objective: Our purpose was to characterize the dorsal contour of the corpus callosum during the first 2 years of life by defining the prevalence, onset and trajectory of notching on midsagittal T1-weighted images. Materials and methods: We reviewed retrospectively 1,157 consecutive patients between birth and 2 years of age. Corpus callosum morphology was evaluated and described. A notch was defined as a dorsal concavity of at least 1 mm in depth along the dorsal surface of the corpus callosum. Patient age as well as notch depth, location, number and presence of the pericallosal artery in the notch were noted. Results: Two hundred thirty-three notches were identified in 549 patients: 36 anterior, 194 posterior and 3 patients with undulations. A statistically significant (R2=0.53, Beta=0.021, P=0.002) positive correlation between posterior notch prevalence and age in months was noted. A positive correlation between age and depth of the posterior notch was also statistically significant (r=0.32, n=179, P≤0.001). A trend for increased anterior notch prevalence with age was identified with significant correlation between visualized pericallosal artery indentation and anterior notching (r=0.20, n=138, P=0.016). Sub-analysis of the first month of life showed corpus callosum notching was not present. Conclusion: The presence of posterior notching increased significantly with age and was more frequent than that of anterior notching. Corpus callosum notching was absent in the first week of life, building on prior studies suggesting corpus callosum notching is acquired. This study provides baseline data on normative corpus callosum notching trajectories by age group during early life, a helpful correlate when associating corpus callosum morphology with disease.

Original languageEnglish (US)
JournalPediatric Radiology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Corpus Callosum
Arteries
Fetal Alcohol Spectrum Disorders
Age Groups
Parturition

Keywords

  • Anomaly
  • Brain
  • Children
  • Corpus callosum
  • Fetal alcohol spectrum disorders
  • Magnetic resonance imaging
  • Notching

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

Morphological changes of the dorsal contour of the corpus callosum during the first two years of life. / Simpson, Lauren N.; Schneble, Erika J.; Griffin, Elena D.; Obayashi, James T.; Setran, Phillip A.; Ross, Donald A.; Pettersson, David R.; Pollock, Jeffrey M.

In: Pediatric Radiology, 01.01.2019.

Research output: Contribution to journalArticle

Simpson, Lauren N. ; Schneble, Erika J. ; Griffin, Elena D. ; Obayashi, James T. ; Setran, Phillip A. ; Ross, Donald A. ; Pettersson, David R. ; Pollock, Jeffrey M. / Morphological changes of the dorsal contour of the corpus callosum during the first two years of life. In: Pediatric Radiology. 2019.
@article{0fcf107259614e6e90323655037ee463,
title = "Morphological changes of the dorsal contour of the corpus callosum during the first two years of life",
abstract = "Background: In the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy. Objective: Our purpose was to characterize the dorsal contour of the corpus callosum during the first 2 years of life by defining the prevalence, onset and trajectory of notching on midsagittal T1-weighted images. Materials and methods: We reviewed retrospectively 1,157 consecutive patients between birth and 2 years of age. Corpus callosum morphology was evaluated and described. A notch was defined as a dorsal concavity of at least 1 mm in depth along the dorsal surface of the corpus callosum. Patient age as well as notch depth, location, number and presence of the pericallosal artery in the notch were noted. Results: Two hundred thirty-three notches were identified in 549 patients: 36 anterior, 194 posterior and 3 patients with undulations. A statistically significant (R2=0.53, Beta=0.021, P=0.002) positive correlation between posterior notch prevalence and age in months was noted. A positive correlation between age and depth of the posterior notch was also statistically significant (r=0.32, n=179, P≤0.001). A trend for increased anterior notch prevalence with age was identified with significant correlation between visualized pericallosal artery indentation and anterior notching (r=0.20, n=138, P=0.016). Sub-analysis of the first month of life showed corpus callosum notching was not present. Conclusion: The presence of posterior notching increased significantly with age and was more frequent than that of anterior notching. Corpus callosum notching was absent in the first week of life, building on prior studies suggesting corpus callosum notching is acquired. This study provides baseline data on normative corpus callosum notching trajectories by age group during early life, a helpful correlate when associating corpus callosum morphology with disease.",
keywords = "Anomaly, Brain, Children, Corpus callosum, Fetal alcohol spectrum disorders, Magnetic resonance imaging, Notching",
author = "Simpson, {Lauren N.} and Schneble, {Erika J.} and Griffin, {Elena D.} and Obayashi, {James T.} and Setran, {Phillip A.} and Ross, {Donald A.} and Pettersson, {David R.} and Pollock, {Jeffrey M.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00247-019-04585-0",
language = "English (US)",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Morphological changes of the dorsal contour of the corpus callosum during the first two years of life

AU - Simpson, Lauren N.

AU - Schneble, Erika J.

AU - Griffin, Elena D.

AU - Obayashi, James T.

AU - Setran, Phillip A.

AU - Ross, Donald A.

AU - Pettersson, David R.

AU - Pollock, Jeffrey M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: In the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy. Objective: Our purpose was to characterize the dorsal contour of the corpus callosum during the first 2 years of life by defining the prevalence, onset and trajectory of notching on midsagittal T1-weighted images. Materials and methods: We reviewed retrospectively 1,157 consecutive patients between birth and 2 years of age. Corpus callosum morphology was evaluated and described. A notch was defined as a dorsal concavity of at least 1 mm in depth along the dorsal surface of the corpus callosum. Patient age as well as notch depth, location, number and presence of the pericallosal artery in the notch were noted. Results: Two hundred thirty-three notches were identified in 549 patients: 36 anterior, 194 posterior and 3 patients with undulations. A statistically significant (R2=0.53, Beta=0.021, P=0.002) positive correlation between posterior notch prevalence and age in months was noted. A positive correlation between age and depth of the posterior notch was also statistically significant (r=0.32, n=179, P≤0.001). A trend for increased anterior notch prevalence with age was identified with significant correlation between visualized pericallosal artery indentation and anterior notching (r=0.20, n=138, P=0.016). Sub-analysis of the first month of life showed corpus callosum notching was not present. Conclusion: The presence of posterior notching increased significantly with age and was more frequent than that of anterior notching. Corpus callosum notching was absent in the first week of life, building on prior studies suggesting corpus callosum notching is acquired. This study provides baseline data on normative corpus callosum notching trajectories by age group during early life, a helpful correlate when associating corpus callosum morphology with disease.

AB - Background: In the medicolegal literature, focal concavities or notching of the corpus callosum has been thought to be associated with fetal alcohol spectrum disorders. Recent work suggests corpus callosum notching is a dynamic and normal anatomical feature, although it has not yet been defined in early life or infancy. Objective: Our purpose was to characterize the dorsal contour of the corpus callosum during the first 2 years of life by defining the prevalence, onset and trajectory of notching on midsagittal T1-weighted images. Materials and methods: We reviewed retrospectively 1,157 consecutive patients between birth and 2 years of age. Corpus callosum morphology was evaluated and described. A notch was defined as a dorsal concavity of at least 1 mm in depth along the dorsal surface of the corpus callosum. Patient age as well as notch depth, location, number and presence of the pericallosal artery in the notch were noted. Results: Two hundred thirty-three notches were identified in 549 patients: 36 anterior, 194 posterior and 3 patients with undulations. A statistically significant (R2=0.53, Beta=0.021, P=0.002) positive correlation between posterior notch prevalence and age in months was noted. A positive correlation between age and depth of the posterior notch was also statistically significant (r=0.32, n=179, P≤0.001). A trend for increased anterior notch prevalence with age was identified with significant correlation between visualized pericallosal artery indentation and anterior notching (r=0.20, n=138, P=0.016). Sub-analysis of the first month of life showed corpus callosum notching was not present. Conclusion: The presence of posterior notching increased significantly with age and was more frequent than that of anterior notching. Corpus callosum notching was absent in the first week of life, building on prior studies suggesting corpus callosum notching is acquired. This study provides baseline data on normative corpus callosum notching trajectories by age group during early life, a helpful correlate when associating corpus callosum morphology with disease.

KW - Anomaly

KW - Brain

KW - Children

KW - Corpus callosum

KW - Fetal alcohol spectrum disorders

KW - Magnetic resonance imaging

KW - Notching

UR - http://www.scopus.com/inward/record.url?scp=85076485581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076485581&partnerID=8YFLogxK

U2 - 10.1007/s00247-019-04585-0

DO - 10.1007/s00247-019-04585-0

M3 - Article

AN - SCOPUS:85076485581

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

ER -