Morphine enhances adenosine release from the in vivo rat chemical cortex

John W. Phillis; Zhigen G. Jiang; Brian J. Chelack; Peter H. Wu

doi:10.1016/0014-2999(80)90215-0

Morphine enhances adenosine release from the in vivo rat chemical cortex

John W. Phillis, Zhigen G. Jiang, Brian J. Chelack, Peter H. Wu

Otolaryngology

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39 Scopus citations

Abstract

Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with ³H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

Original language	English (US)
Pages (from-to)	97-100
Number of pages	4
Journal	European Journal of Pharmacology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(80)90215-0
State	Published - 1980

Keywords

Adenosine release
Cerebral cortex
Morphine

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(80)90215-0

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title = "Morphine enhances adenosine release from the in vivo rat chemical cortex",

abstract = "Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.",

keywords = "Adenosine release, Cerebral cortex, Morphine",

author = "Phillis, {John W.} and Jiang, {Zhigen G.} and Chelack, {Brian J.} and Wu, {Peter H.}",

year = "1980",

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T1 - Morphine enhances adenosine release from the in vivo rat chemical cortex

AU - Phillis, John W.

AU - Jiang, Zhigen G.

AU - Chelack, Brian J.

AU - Wu, Peter H.

PY - 1980

Y1 - 1980

N2 - Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

AB - Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

KW - Adenosine release

KW - Cerebral cortex

KW - Morphine

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JF - European Journal of Pharmacology

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ER -

Morphine enhances adenosine release from the in vivo rat chemical cortex

Abstract

Keywords

ASJC Scopus subject areas

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