Morphine enhances adenosine release from the in vivo rat chemical cortex

John W. Phillis, Zhigen G. Jiang, Brian J. Chelack, Peter H. Wu

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalEuropean Journal of Pharmacology
Volume65
Issue number1
DOIs
StatePublished - Jan 1 1980

Keywords

  • Adenosine release
  • Cerebral cortex
  • Morphine

ASJC Scopus subject areas

  • Pharmacology

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