Mood response to levodopa infusion in early Parkinson's disease

Robert A. Maricle; Rita J. Valentine; Julie Carter; John G. Nutt

doi:10.1212/WNL.50.6.1890

Mood response to levodopa infusion in early Parkinson's disease

Robert A. Maricle, Rita J. Valentine, Julie Carter, John G. Nutt

Neurology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Mood response to levodopa infusion was studied in 18 Parkinson's disease (PD) patients during the first year of levodopa therapy before and after 2- hour (1.0 mg/kg/h) levodopa infusions at baseline and 6- and 12-month follow- up. Mood elevation was greatest after a 2-day levodopa holiday at the 6- and 12-month assessments. Age, sex, duration and severity of PD, and ongoing oral levodopa dose did not correlate with mood response. Mood response in these patients differs from that seen in advanced patients, possibly because of sensitization to levodopa's mood effects.

Original language	English (US)
Pages (from-to)	1890-1892
Number of pages	3
Journal	Neurology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1212/WNL.50.6.1890
State	Published - Jun 1998

ASJC Scopus subject areas

Clinical Neurology

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title = "Mood response to levodopa infusion in early Parkinson's disease",

abstract = "Mood response to levodopa infusion was studied in 18 Parkinson's disease (PD) patients during the first year of levodopa therapy before and after 2- hour (1.0 mg/kg/h) levodopa infusions at baseline and 6- and 12-month follow- up. Mood elevation was greatest after a 2-day levodopa holiday at the 6- and 12-month assessments. Age, sex, duration and severity of PD, and ongoing oral levodopa dose did not correlate with mood response. Mood response in these patients differs from that seen in advanced patients, possibly because of sensitization to levodopa's mood effects.",

author = "Maricle, {Robert A.} and Valentine, {Rita J.} and Julie Carter and Nutt, {John G.}",

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AU - Valentine, Rita J.

AU - Carter, Julie

AU - Nutt, John G.

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N2 - Mood response to levodopa infusion was studied in 18 Parkinson's disease (PD) patients during the first year of levodopa therapy before and after 2- hour (1.0 mg/kg/h) levodopa infusions at baseline and 6- and 12-month follow- up. Mood elevation was greatest after a 2-day levodopa holiday at the 6- and 12-month assessments. Age, sex, duration and severity of PD, and ongoing oral levodopa dose did not correlate with mood response. Mood response in these patients differs from that seen in advanced patients, possibly because of sensitization to levodopa's mood effects.

AB - Mood response to levodopa infusion was studied in 18 Parkinson's disease (PD) patients during the first year of levodopa therapy before and after 2- hour (1.0 mg/kg/h) levodopa infusions at baseline and 6- and 12-month follow- up. Mood elevation was greatest after a 2-day levodopa holiday at the 6- and 12-month assessments. Age, sex, duration and severity of PD, and ongoing oral levodopa dose did not correlate with mood response. Mood response in these patients differs from that seen in advanced patients, possibly because of sensitization to levodopa's mood effects.

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Mood response to levodopa infusion in early Parkinson's disease

Abstract

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