Mood response to levodopa infusion in early Parkinson's disease

Robert A. Maricle, Rita J. Valentine, Julie Carter, John Nutt

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Mood response to levodopa infusion was studied in 18 Parkinson's disease (PD) patients during the first year of levodopa therapy before and after 2- hour (1.0 mg/kg/h) levodopa infusions at baseline and 6- and 12-month follow- up. Mood elevation was greatest after a 2-day levodopa holiday at the 6- and 12-month assessments. Age, sex, duration and severity of PD, and ongoing oral levodopa dose did not correlate with mood response. Mood response in these patients differs from that seen in advanced patients, possibly because of sensitization to levodopa's mood effects.

Original languageEnglish (US)
Pages (from-to)1890-1892
Number of pages3
JournalNeurology
Volume50
Issue number6
StatePublished - Jun 1998

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Levodopa
Parkinson Disease
Holidays

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maricle, R. A., Valentine, R. J., Carter, J., & Nutt, J. (1998). Mood response to levodopa infusion in early Parkinson's disease. Neurology, 50(6), 1890-1892.

Mood response to levodopa infusion in early Parkinson's disease. / Maricle, Robert A.; Valentine, Rita J.; Carter, Julie; Nutt, John.

In: Neurology, Vol. 50, No. 6, 06.1998, p. 1890-1892.

Research output: Contribution to journalArticle

Maricle, RA, Valentine, RJ, Carter, J & Nutt, J 1998, 'Mood response to levodopa infusion in early Parkinson's disease', Neurology, vol. 50, no. 6, pp. 1890-1892.
Maricle RA, Valentine RJ, Carter J, Nutt J. Mood response to levodopa infusion in early Parkinson's disease. Neurology. 1998 Jun;50(6):1890-1892.
Maricle, Robert A. ; Valentine, Rita J. ; Carter, Julie ; Nutt, John. / Mood response to levodopa infusion in early Parkinson's disease. In: Neurology. 1998 ; Vol. 50, No. 6. pp. 1890-1892.
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