Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats

Reiko Takeshima, Jeffrey Kirsch, Raymond C. Koehler, Allen W. Gomoll, Richard J. Traystman

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Background and Purpose: We tested the hypothesis that inhibition of leukocyte function by administration of monoclonal antibody 60.3 (MoAb 60.3) improves electrophysiological recovery and decreases injury volume following transient focal cerebral ischemia in cats. Methods: Halothane-anesthetized cats underwent 90 minutes of left middle cerebral artery and bilateral common carotid artery occlusion followed by 180 minutes of reperfusion. Cats were assigned to receive either 2 mg/kg MoAb 60.3 (n=8) directed at the CDw18 leukocyte antigen complex or an equal volume of diluent (sterile saline; n = 10) at 45 minutes of ischemia in a blinded fashion. Results: Blood flow to the left temporoparietal cortex decreased to

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalStroke
Volume23
Issue number2
Publication statusPublished - 1992
Externally publishedYes

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Keywords

  • Cats
  • Cerebral blood flow
  • Evoked potentials
  • Leukocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Takeshima, R., Kirsch, J., Koehler, R. C., Gomoll, A. W., & Traystman, R. J. (1992). Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats. Stroke, 23(2), 247-252.