Molecular operation on elastic fibers and cholesterol ester by a free electron laser

Kunio Awazu, Seiji Ogino, Akio Nagai, Takio Tomimasu, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A method has been found to selectively ablate cholesterol esters accumulated in an arteriosclerotic region of a rabbit artery without damaging the blood vessel using a free-electron laser (FEL). A FEL is a pulsed laser source that generates a beam by amplifying the coherent radiation emitted by an electron beam that is travelling through a periodically alternating magnetic field at a relativistic velocity. The characteristics of the FEL include a broadly tunable wavelength and ukra-short pulse width. We have found that FEL irradiation of a rabbit arterial wall for 1 min with a power of 1.5 mW can ablate cholesterol esters without damaging the elastic fibers of the arterial wall. The FEL was tuned to 5.75 μm, which is a wavelength that is absorbed by cholesterol ester. This method may be used as a non-invasive surgical procedure for the treatment of arteriosclerotic arteries.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.P. Delacretaz, G.M.D. Godlewski, R. Pini, R.W. Steiner, L.O. Svaasand, A. Katzir
Pages225-231
Number of pages7
Volume3195
DOIs
StatePublished - 1997
Externally publishedYes
EventProceedings of Lasers-Tissue Interaction, Tissue Optics and Laser Welding III - San Remo, Italy
Duration: Sep 5 1997Sep 8 1997

Other

OtherProceedings of Lasers-Tissue Interaction, Tissue Optics and Laser Welding III
CountryItaly
CitySan Remo
Period9/5/979/8/97

Fingerprint

Free electron lasers
Cholesterol
cholesterol
free electron lasers
esters
Esters
fibers
Fibers
rabbits
arteries
relativistic velocity
Wavelength
coherent radiation
blood vessels
Blood vessels
Laser beam effects
Pulsed lasers
wavelengths
Light sources
Electron beams

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Awazu, K., Ogino, S., Nagai, A., Tomimasu, T., & Jacques, S. (1997). Molecular operation on elastic fibers and cholesterol ester by a free electron laser. In G. P. Delacretaz, G. M. D. Godlewski, R. Pini, R. W. Steiner, L. O. Svaasand, & A. Katzir (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3195, pp. 225-231) https://doi.org/10.1117/12.297906

Molecular operation on elastic fibers and cholesterol ester by a free electron laser. / Awazu, Kunio; Ogino, Seiji; Nagai, Akio; Tomimasu, Takio; Jacques, Steven.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.P. Delacretaz; G.M.D. Godlewski; R. Pini; R.W. Steiner; L.O. Svaasand; A. Katzir. Vol. 3195 1997. p. 225-231.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Awazu, K, Ogino, S, Nagai, A, Tomimasu, T & Jacques, S 1997, Molecular operation on elastic fibers and cholesterol ester by a free electron laser. in GP Delacretaz, GMD Godlewski, R Pini, RW Steiner, LO Svaasand & A Katzir (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 3195, pp. 225-231, Proceedings of Lasers-Tissue Interaction, Tissue Optics and Laser Welding III, San Remo, Italy, 9/5/97. https://doi.org/10.1117/12.297906
Awazu K, Ogino S, Nagai A, Tomimasu T, Jacques S. Molecular operation on elastic fibers and cholesterol ester by a free electron laser. In Delacretaz GP, Godlewski GMD, Pini R, Steiner RW, Svaasand LO, Katzir A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3195. 1997. p. 225-231 https://doi.org/10.1117/12.297906
Awazu, Kunio ; Ogino, Seiji ; Nagai, Akio ; Tomimasu, Takio ; Jacques, Steven. / Molecular operation on elastic fibers and cholesterol ester by a free electron laser. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.P. Delacretaz ; G.M.D. Godlewski ; R. Pini ; R.W. Steiner ; L.O. Svaasand ; A. Katzir. Vol. 3195 1997. pp. 225-231
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