Molecular genetic diversity in 5 populations of Madhya Pradesh, India

S. S. Mastana, P (Hemachandra) Reddy, M. K. Das, P. Reddy, K. Das

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This paper presents data on the distribution of 3 amplified fragment length polymorphisms (D1S80, APOB, and YNZ22) in 5 populations of Central India. Using the polymerase chain reaction technique, 3 caste (Brahmin, Khatri, and Dhimer) and 2 tribal (Gond and Baiga) populations were studied for the 3 loci. The allelic variations observed in the caste populations are compatible with those of many Caucasian populations, but the caste populations showed significant overall and interpopulation variability within the region. D1S80 allele *24 varied from 32% (Dhimers) to 42% (Brahmins). Allele *18 was not observed in Baiga tribal populations, but in caste populations it varied from 11% (Dhimers) to 24% (Brahmins). Both tribal populations showed higher frequencies of allele *31 (17%-18%). For APOB, caste populations again showed bimodal distribution of alleles *35 and *37, but in tribal populations higher allele numbers (*47, *49) were also frequent. For YNZ22, extensive variation was observed for all populations studied. Allele *4 was the most common in caste populations, while alleles *2, *7, and *10 were prominent in tribal populations. The level of gene differentiation is not very high for the 3 systems studied in the 5 populations. Overall, allele frequency distribution, heterozygosity, and genetic diversity analysis show that the genetic diversity observed is socially and geographically structured.

Original languageEnglish (US)
Pages (from-to)499-510
Number of pages12
JournalHuman Biology
Volume72
Issue number3
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

molecular genetics
caste
Molecular Biology
India
allele
genetic variation
Population
Social Class
Alleles
alleles
genetic diversity
Gene Frequency
gene frequency
heterozygosity
polymerase chain reaction
polymorphism
gene
amplified fragment length polymorphism
distribution

Keywords

  • India
  • RFLP
  • Tribal population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Mastana, S. S., Reddy, P. H., Das, M. K., Reddy, P., & Das, K. (2000). Molecular genetic diversity in 5 populations of Madhya Pradesh, India. Human Biology, 72(3), 499-510.

Molecular genetic diversity in 5 populations of Madhya Pradesh, India. / Mastana, S. S.; Reddy, P (Hemachandra); Das, M. K.; Reddy, P.; Das, K.

In: Human Biology, Vol. 72, No. 3, 06.2000, p. 499-510.

Research output: Contribution to journalArticle

Mastana, SS, Reddy, PH, Das, MK, Reddy, P & Das, K 2000, 'Molecular genetic diversity in 5 populations of Madhya Pradesh, India', Human Biology, vol. 72, no. 3, pp. 499-510.
Mastana SS, Reddy PH, Das MK, Reddy P, Das K. Molecular genetic diversity in 5 populations of Madhya Pradesh, India. Human Biology. 2000 Jun;72(3):499-510.
Mastana, S. S. ; Reddy, P (Hemachandra) ; Das, M. K. ; Reddy, P. ; Das, K. / Molecular genetic diversity in 5 populations of Madhya Pradesh, India. In: Human Biology. 2000 ; Vol. 72, No. 3. pp. 499-510.
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