Molecular genetic diversity in 5 populations of Madhya Pradesh, India

S. S. Mastana, P. H. Reddy, M. K. Das, P. Reddy, K. Das

    Research output: Contribution to journalArticle

    7 Scopus citations

    Abstract

    This paper presents data on the distribution of 3 amplified fragment length polymorphisms (D1S80, APOB, and YNZ22) in 5 populations of Central India. Using the polymerase chain reaction technique, 3 caste (Brahmin, Khatri, and Dhimer) and 2 tribal (Gond and Baiga) populations were studied for the 3 loci. The allelic variations observed in the caste populations are compatible with those of many Caucasian populations, but the caste populations showed significant overall and interpopulation variability within the region. D1S80 allele *24 varied from 32% (Dhimers) to 42% (Brahmins). Allele *18 was not observed in Baiga tribal populations, but in caste populations it varied from 11% (Dhimers) to 24% (Brahmins). Both tribal populations showed higher frequencies of allele *31 (17%-18%). For APOB, caste populations again showed bimodal distribution of alleles *35 and *37, but in tribal populations higher allele numbers (*47, *49) were also frequent. For YNZ22, extensive variation was observed for all populations studied. Allele *4 was the most common in caste populations, while alleles *2, *7, and *10 were prominent in tribal populations. The level of gene differentiation is not very high for the 3 systems studied in the 5 populations. Overall, allele frequency distribution, heterozygosity, and genetic diversity analysis show that the genetic diversity observed is socially and geographically structured.

    Original languageEnglish (US)
    Pages (from-to)499-510
    Number of pages12
    JournalHuman Biology
    Volume72
    Issue number3
    StatePublished - Jun 1 2000

    Keywords

    • India
    • RFLP
    • Tribal population

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Genetics(clinical)

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  • Cite this

    Mastana, S. S., Reddy, P. H., Das, M. K., Reddy, P., & Das, K. (2000). Molecular genetic diversity in 5 populations of Madhya Pradesh, India. Human Biology, 72(3), 499-510.