Molecular Composition of Vestibular Hair Bundles

Jocelyn F. Krey, Peter Barr-Gillespie

Research output: Contribution to journalReview article

Abstract

The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a description of the consensus composition of vestibular bundles of mouse, rat, and chick.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 2 2019

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Cellular Mechanotransduction
Stereocilia
Biochemistry
Vertebrates
Rats
Actins
Cells
Lipids
Imaging techniques
Chemical analysis
Proteins
Genetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Molecular Composition of Vestibular Hair Bundles. / Krey, Jocelyn F.; Barr-Gillespie, Peter.

In: Cold Spring Harbor perspectives in medicine, Vol. 9, No. 1, 02.01.2019.

Research output: Contribution to journalReview article

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