Molecular biology of antibiotic production in Bacillus.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Several species of the genus Bacillus produce peptide antibiotics which are synthesized either through a ribosomal or non-ribosomal mechanism. The antibiotics gramicidin, tyrocidine, and bacitracin are synthesized nonribosomally by the multienzyme thiotemplate mechanism. Surfactin and mycobacillin are also synthesized nonribosomally but by a mechanism that, apparently, is distinct from that of the multienzyme thiotemplate. Other antibiotics such as subtilin are gene encoded and are ribosomally synthesized. Molecular genetic and DNA sequence analysis have shown that biosynthesis genes for some antibiotics are clustered into polycistronic transcription units and are under the control of global regulatory systems that govern the expression of genes that are induced when Bacillus cells enter stationary phase of growth. Future experiments involving the molecular dissection of peptide antibiotic biosynthesis genes in Bacillus will be attempted in hopes of further examining the mechanism and regulation of antibiotic production.

Original languageEnglish (US)
Pages (from-to)223-240
Number of pages18
JournalCritical Reviews in Biotechnology
Volume10
Issue number3
StatePublished - 1990
Externally publishedYes

Fingerprint

Bacillus
Molecular Biology
Anti-Bacterial Agents
Mycobacillin
Tyrocidine
Peptide Biosynthesis
Genes
Bacitracin
Gramicidin
DNA Sequence Analysis
Dissection
Gene Expression
Peptides
Growth

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Molecular biology of antibiotic production in Bacillus. / Nakano, Michiko; Zuber, Peter.

In: Critical Reviews in Biotechnology, Vol. 10, No. 3, 1990, p. 223-240.

Research output: Contribution to journalArticle

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