Molecular architecture of the zebra finch arcopallium

Claudio Mello, Taylor Kaser, Alexa A. Buckner, Morgan Wirthlin, Peter V. Lovell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Here we present a molecular characterization of the arcopallium in the zebra finch, a passerine songbird species and a major model organism for vocal learning studies. Based on in situ hybridization for arcopallial-expressed transcripts (AQP1, C1QL3, CBLN2, CNTN4, CYP19A1, ESR1/2, FEZF2, MGP, NECAB2, PCP4, PVALB, SCN3B, SCUBE1, ZBTB20, and others) in comparison with cytoarchitectonic features, we have defined 20 distinct regions that can be grouped into six major domains (anterior, posterior, dorsal, ventral, medial, and intermediate arcopallium, respectively; AA, AP, AD, AV, AM, and AI). The data also help to establish the arcopallium as primarily pallial, support a unique topography of the arcopallium in passerines, highlight similarities between the vocal robust nucleus of the arcopallium (RA) and AI, and provide insights into the similarities and differences of cortical and amygdalar regions between birds and mammals. We also propose the use of AMV (instead of nucleus taenia/TnA), AMD, AD, and AI as initial steps toward a universal arcopallial nomenclature. Besides clarifying the internal organization of the arcopallium, the data provide a coherent basis for further functional and comparative studies of this complex avian brain region.

Original languageEnglish (US)
JournalJournal of Comparative Neurology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Finches
Equidae
Taenia
Songbirds
Brain
Prosencephalon
Terminology
Birds
In Situ Hybridization
Mammals
Learning

Keywords

  • amygdala
  • avian
  • cortical layers
  • in situ hybridization
  • molecularly defined brain regions
  • oscine songbird
  • RRID: SCR_012988)
  • taenia
  • ZEBrA (www.zebrafinchatlas.org)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular architecture of the zebra finch arcopallium. / Mello, Claudio; Kaser, Taylor; Buckner, Alexa A.; Wirthlin, Morgan; Lovell, Peter V.

In: Journal of Comparative Neurology, 01.01.2019.

Research output: Contribution to journalArticle

Mello, Claudio ; Kaser, Taylor ; Buckner, Alexa A. ; Wirthlin, Morgan ; Lovell, Peter V. / Molecular architecture of the zebra finch arcopallium. In: Journal of Comparative Neurology. 2019.
@article{b5f3c884476d48c987653728e32d4157,
title = "Molecular architecture of the zebra finch arcopallium",
abstract = "The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Here we present a molecular characterization of the arcopallium in the zebra finch, a passerine songbird species and a major model organism for vocal learning studies. Based on in situ hybridization for arcopallial-expressed transcripts (AQP1, C1QL3, CBLN2, CNTN4, CYP19A1, ESR1/2, FEZF2, MGP, NECAB2, PCP4, PVALB, SCN3B, SCUBE1, ZBTB20, and others) in comparison with cytoarchitectonic features, we have defined 20 distinct regions that can be grouped into six major domains (anterior, posterior, dorsal, ventral, medial, and intermediate arcopallium, respectively; AA, AP, AD, AV, AM, and AI). The data also help to establish the arcopallium as primarily pallial, support a unique topography of the arcopallium in passerines, highlight similarities between the vocal robust nucleus of the arcopallium (RA) and AI, and provide insights into the similarities and differences of cortical and amygdalar regions between birds and mammals. We also propose the use of AMV (instead of nucleus taenia/TnA), AMD, AD, and AI as initial steps toward a universal arcopallial nomenclature. Besides clarifying the internal organization of the arcopallium, the data provide a coherent basis for further functional and comparative studies of this complex avian brain region.",
keywords = "amygdala, avian, cortical layers, in situ hybridization, molecularly defined brain regions, oscine songbird, RRID: SCR_012988), taenia, ZEBrA (www.zebrafinchatlas.org)",
author = "Claudio Mello and Taylor Kaser and Buckner, {Alexa A.} and Morgan Wirthlin and Lovell, {Peter V.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/cne.24688",
language = "English (US)",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Molecular architecture of the zebra finch arcopallium

AU - Mello, Claudio

AU - Kaser, Taylor

AU - Buckner, Alexa A.

AU - Wirthlin, Morgan

AU - Lovell, Peter V.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Here we present a molecular characterization of the arcopallium in the zebra finch, a passerine songbird species and a major model organism for vocal learning studies. Based on in situ hybridization for arcopallial-expressed transcripts (AQP1, C1QL3, CBLN2, CNTN4, CYP19A1, ESR1/2, FEZF2, MGP, NECAB2, PCP4, PVALB, SCN3B, SCUBE1, ZBTB20, and others) in comparison with cytoarchitectonic features, we have defined 20 distinct regions that can be grouped into six major domains (anterior, posterior, dorsal, ventral, medial, and intermediate arcopallium, respectively; AA, AP, AD, AV, AM, and AI). The data also help to establish the arcopallium as primarily pallial, support a unique topography of the arcopallium in passerines, highlight similarities between the vocal robust nucleus of the arcopallium (RA) and AI, and provide insights into the similarities and differences of cortical and amygdalar regions between birds and mammals. We also propose the use of AMV (instead of nucleus taenia/TnA), AMD, AD, and AI as initial steps toward a universal arcopallial nomenclature. Besides clarifying the internal organization of the arcopallium, the data provide a coherent basis for further functional and comparative studies of this complex avian brain region.

AB - The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Here we present a molecular characterization of the arcopallium in the zebra finch, a passerine songbird species and a major model organism for vocal learning studies. Based on in situ hybridization for arcopallial-expressed transcripts (AQP1, C1QL3, CBLN2, CNTN4, CYP19A1, ESR1/2, FEZF2, MGP, NECAB2, PCP4, PVALB, SCN3B, SCUBE1, ZBTB20, and others) in comparison with cytoarchitectonic features, we have defined 20 distinct regions that can be grouped into six major domains (anterior, posterior, dorsal, ventral, medial, and intermediate arcopallium, respectively; AA, AP, AD, AV, AM, and AI). The data also help to establish the arcopallium as primarily pallial, support a unique topography of the arcopallium in passerines, highlight similarities between the vocal robust nucleus of the arcopallium (RA) and AI, and provide insights into the similarities and differences of cortical and amygdalar regions between birds and mammals. We also propose the use of AMV (instead of nucleus taenia/TnA), AMD, AD, and AI as initial steps toward a universal arcopallial nomenclature. Besides clarifying the internal organization of the arcopallium, the data provide a coherent basis for further functional and comparative studies of this complex avian brain region.

KW - amygdala

KW - avian

KW - cortical layers

KW - in situ hybridization

KW - molecularly defined brain regions

KW - oscine songbird

KW - RRID: SCR_012988)

KW - taenia

KW - ZEBrA (www.zebrafinchatlas.org)

UR - http://www.scopus.com/inward/record.url?scp=85065399059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065399059&partnerID=8YFLogxK

U2 - 10.1002/cne.24688

DO - 10.1002/cne.24688

M3 - Article

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

ER -