Molecular analysis of commensal host-microbial relationships in the intestine

L. V. Hooper, M. H. Wong, A. Thelin, L. Hansson, P. G. Falk, J. I. Gordon

    Research output: Contribution to journalArticle

    1469 Scopus citations


    Human beings contain complex societies of indigenous microbes, yet little is known about how resident bacteria shape our physiology. We colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the normal mouse and human intestinal microflora. Global intestinal transcriptional responses to colonization were observed with DNA microarrays, and the cellular origins of selected responses were established by laser-capture microdissection. The results reveal that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation. These findings provide perspectives about the essential nature of the interactions between resident microorganisms and their hosts.

    Original languageEnglish (US)
    Pages (from-to)881-884
    Number of pages4
    Issue number5505
    StatePublished - Feb 2 2001

    ASJC Scopus subject areas

    • General

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    Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001). Molecular analysis of commensal host-microbial relationships in the intestine. Science, 291(5505), 881-884.