Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: Results of a multiinstitutional series with an analysis of the extent of microscopic spread

D. Ratner, C. O. Thomas, T. M. Johnson, V. K. Sondak, T. A. Hamilton, B. R. Nelson, Neil Swanson, C. Garcia, R. E. Clark, D. J. Grande

Research output: Contribution to journalArticle

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Abstract

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft- tissue tumor of the skin; its microscopic extent of invasion beyond the grossly visible tumor is frequently difficult to appreciate. Although wide local excision has been the standard treatment of DFSP, recurrence rates range from 11% to 53%. Because Mohs micrographic surgery allows the extent of excision to be tailored to the microscopic extent of tumor, we evaluated this technique for the treatment of primary and recurrent DFSP. Objective: Our purpose was to determine the local recurrence rate and microscopic extent of spread of primary and recurrent DFSP after treatment with Mohs micrographic surgery. Methods: The records of 58 patients with primary and recurrent DFSP treated with Mohs micrographic surgery at three institutions were reviewed and the macroscopic and microscopic extents of tumor were recorded. Results: One patient with a twice-recurrent DFSP had another recurrence after Mohs micrographic surgery, for an overall local recurrence rate of 2% (zero for primary tumors and 4.8% for recurrent tumors). There were no cases of regional or distant metastases. Macroscopic tumor size ranged from 0.3 x 0.6 cm to 30 x 20 cm, whereas microscopic (postoperative) size ranged from 1.8 x 1.0 cm to 35 x 40 cm. We calculated the likelihood that a given width of excision around the macroscopic tumor would clear the entire microscopic extent of tumor. Standard wide excision with a width of 1 cm around the primary tumor would have left microscopic residual tumor in 70.7%; a width of 2 cm, 39.7%; 3 cm, 15.5%; and 5 cm, 5.2%. Even an excision width of 10 cm would not have cleared the microscopic extent of some tumors, despite taking a huge excess of normal tissue. Conclusion: Treatment of primary and recurrent DFSP by Mohs micrographic surgery results in a low recurrence rate because of the ability of the technique to permit the detection and excision of microscopic tumor elements in even the most asymmetric tumors. Whatever type of surgery is chosen to treat DFSP, it is necessary to assess the entire perimeter of the tumor for microscopic extension and to achieve tumor-free margins in all directions.

Original languageEnglish (US)
Pages (from-to)600-613
Number of pages14
JournalJournal of the American Academy of Dermatology
Volume37
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

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Dermatofibrosarcoma
Mohs Surgery
Neoplasms
Therapeutics
Recurrence
Residual Neoplasm

ASJC Scopus subject areas

  • Dermatology

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Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans : Results of a multiinstitutional series with an analysis of the extent of microscopic spread. / Ratner, D.; Thomas, C. O.; Johnson, T. M.; Sondak, V. K.; Hamilton, T. A.; Nelson, B. R.; Swanson, Neil; Garcia, C.; Clark, R. E.; Grande, D. J.

In: Journal of the American Academy of Dermatology, Vol. 37, No. 4, 1997, p. 600-613.

Research output: Contribution to journalArticle

Ratner, D. ; Thomas, C. O. ; Johnson, T. M. ; Sondak, V. K. ; Hamilton, T. A. ; Nelson, B. R. ; Swanson, Neil ; Garcia, C. ; Clark, R. E. ; Grande, D. J. / Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans : Results of a multiinstitutional series with an analysis of the extent of microscopic spread. In: Journal of the American Academy of Dermatology. 1997 ; Vol. 37, No. 4. pp. 600-613.
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title = "Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: Results of a multiinstitutional series with an analysis of the extent of microscopic spread",
abstract = "Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft- tissue tumor of the skin; its microscopic extent of invasion beyond the grossly visible tumor is frequently difficult to appreciate. Although wide local excision has been the standard treatment of DFSP, recurrence rates range from 11{\%} to 53{\%}. Because Mohs micrographic surgery allows the extent of excision to be tailored to the microscopic extent of tumor, we evaluated this technique for the treatment of primary and recurrent DFSP. Objective: Our purpose was to determine the local recurrence rate and microscopic extent of spread of primary and recurrent DFSP after treatment with Mohs micrographic surgery. Methods: The records of 58 patients with primary and recurrent DFSP treated with Mohs micrographic surgery at three institutions were reviewed and the macroscopic and microscopic extents of tumor were recorded. Results: One patient with a twice-recurrent DFSP had another recurrence after Mohs micrographic surgery, for an overall local recurrence rate of 2{\%} (zero for primary tumors and 4.8{\%} for recurrent tumors). There were no cases of regional or distant metastases. Macroscopic tumor size ranged from 0.3 x 0.6 cm to 30 x 20 cm, whereas microscopic (postoperative) size ranged from 1.8 x 1.0 cm to 35 x 40 cm. We calculated the likelihood that a given width of excision around the macroscopic tumor would clear the entire microscopic extent of tumor. Standard wide excision with a width of 1 cm around the primary tumor would have left microscopic residual tumor in 70.7{\%}; a width of 2 cm, 39.7{\%}; 3 cm, 15.5{\%}; and 5 cm, 5.2{\%}. Even an excision width of 10 cm would not have cleared the microscopic extent of some tumors, despite taking a huge excess of normal tissue. Conclusion: Treatment of primary and recurrent DFSP by Mohs micrographic surgery results in a low recurrence rate because of the ability of the technique to permit the detection and excision of microscopic tumor elements in even the most asymmetric tumors. Whatever type of surgery is chosen to treat DFSP, it is necessary to assess the entire perimeter of the tumor for microscopic extension and to achieve tumor-free margins in all directions.",
author = "D. Ratner and Thomas, {C. O.} and Johnson, {T. M.} and Sondak, {V. K.} and Hamilton, {T. A.} and Nelson, {B. R.} and Neil Swanson and C. Garcia and Clark, {R. E.} and Grande, {D. J.}",
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T1 - Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans

T2 - Results of a multiinstitutional series with an analysis of the extent of microscopic spread

AU - Ratner, D.

AU - Thomas, C. O.

AU - Johnson, T. M.

AU - Sondak, V. K.

AU - Hamilton, T. A.

AU - Nelson, B. R.

AU - Swanson, Neil

AU - Garcia, C.

AU - Clark, R. E.

AU - Grande, D. J.

PY - 1997

Y1 - 1997

N2 - Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft- tissue tumor of the skin; its microscopic extent of invasion beyond the grossly visible tumor is frequently difficult to appreciate. Although wide local excision has been the standard treatment of DFSP, recurrence rates range from 11% to 53%. Because Mohs micrographic surgery allows the extent of excision to be tailored to the microscopic extent of tumor, we evaluated this technique for the treatment of primary and recurrent DFSP. Objective: Our purpose was to determine the local recurrence rate and microscopic extent of spread of primary and recurrent DFSP after treatment with Mohs micrographic surgery. Methods: The records of 58 patients with primary and recurrent DFSP treated with Mohs micrographic surgery at three institutions were reviewed and the macroscopic and microscopic extents of tumor were recorded. Results: One patient with a twice-recurrent DFSP had another recurrence after Mohs micrographic surgery, for an overall local recurrence rate of 2% (zero for primary tumors and 4.8% for recurrent tumors). There were no cases of regional or distant metastases. Macroscopic tumor size ranged from 0.3 x 0.6 cm to 30 x 20 cm, whereas microscopic (postoperative) size ranged from 1.8 x 1.0 cm to 35 x 40 cm. We calculated the likelihood that a given width of excision around the macroscopic tumor would clear the entire microscopic extent of tumor. Standard wide excision with a width of 1 cm around the primary tumor would have left microscopic residual tumor in 70.7%; a width of 2 cm, 39.7%; 3 cm, 15.5%; and 5 cm, 5.2%. Even an excision width of 10 cm would not have cleared the microscopic extent of some tumors, despite taking a huge excess of normal tissue. Conclusion: Treatment of primary and recurrent DFSP by Mohs micrographic surgery results in a low recurrence rate because of the ability of the technique to permit the detection and excision of microscopic tumor elements in even the most asymmetric tumors. Whatever type of surgery is chosen to treat DFSP, it is necessary to assess the entire perimeter of the tumor for microscopic extension and to achieve tumor-free margins in all directions.

AB - Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft- tissue tumor of the skin; its microscopic extent of invasion beyond the grossly visible tumor is frequently difficult to appreciate. Although wide local excision has been the standard treatment of DFSP, recurrence rates range from 11% to 53%. Because Mohs micrographic surgery allows the extent of excision to be tailored to the microscopic extent of tumor, we evaluated this technique for the treatment of primary and recurrent DFSP. Objective: Our purpose was to determine the local recurrence rate and microscopic extent of spread of primary and recurrent DFSP after treatment with Mohs micrographic surgery. Methods: The records of 58 patients with primary and recurrent DFSP treated with Mohs micrographic surgery at three institutions were reviewed and the macroscopic and microscopic extents of tumor were recorded. Results: One patient with a twice-recurrent DFSP had another recurrence after Mohs micrographic surgery, for an overall local recurrence rate of 2% (zero for primary tumors and 4.8% for recurrent tumors). There were no cases of regional or distant metastases. Macroscopic tumor size ranged from 0.3 x 0.6 cm to 30 x 20 cm, whereas microscopic (postoperative) size ranged from 1.8 x 1.0 cm to 35 x 40 cm. We calculated the likelihood that a given width of excision around the macroscopic tumor would clear the entire microscopic extent of tumor. Standard wide excision with a width of 1 cm around the primary tumor would have left microscopic residual tumor in 70.7%; a width of 2 cm, 39.7%; 3 cm, 15.5%; and 5 cm, 5.2%. Even an excision width of 10 cm would not have cleared the microscopic extent of some tumors, despite taking a huge excess of normal tissue. Conclusion: Treatment of primary and recurrent DFSP by Mohs micrographic surgery results in a low recurrence rate because of the ability of the technique to permit the detection and excision of microscopic tumor elements in even the most asymmetric tumors. Whatever type of surgery is chosen to treat DFSP, it is necessary to assess the entire perimeter of the tumor for microscopic extension and to achieve tumor-free margins in all directions.

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