Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells

Caroline Enns, Mary A. Mulkins, Howard Sussman, Barbara Root

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18 Scopus citations


When HL-60 cells are induced to differentiate by dimethyl sulfoxide along a granulocytic pathway there is a fivefold decrease in the total number of transferrin receptors within 3 days, as compared to untreated cells. This decrease is due primarily to a rapid decline in the synthesis of the receptor rather than an increase in the degradation of the receptor. The decrease in transferrin receptor synthesis is a specific and early event that precedes the cessation of cell proliferation, differentiation, and the decrease in total protein synthesis.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalExperimental Cell Research
Issue number1
Publication statusPublished - 1988
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology

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