Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6

Stelios Georgiades; Michael Boyle; Peter Szatmari; Steven Hanna; Eric Duku; Lonnie Zwaigenbaum; Susan Bryson; Eric Fombonne; Joanne Volden; Pat Mirenda; Isabel Smith; Wendy Roberts; Tracy Vaillancourt; Charlotte Waddell; Teresa Bennett; Mayada Elsabbagh; Ann Thompson

doi:10.1007/s10803-014-2167-x

Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6

Stelios Georgiades, Michael Boyle, Peter Szatmari, Steven Hanna, Eric Duku, Lonnie Zwaigenbaum, Susan Bryson, Eric Fombonne, Joanne Volden, Pat Mirenda, Isabel Smith, Wendy Roberts, Tracy Vaillancourt, Charlotte Waddell, Teresa Bennett, Mayada Elsabbagh, Ann Thompson

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a “2-factor/3-class” model provided the best fit to the data. At Time 2, a “2-factor/2-class” model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the “2-factor/3-class” model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity.

Original language	English (US)
Pages (from-to)	3045-3055
Number of pages	11
Journal	Journal of autism and developmental disorders
Volume	44
Issue number	12
DOIs	https://doi.org/10.1007/s10803-014-2167-x
State	Published - Dec 1 2014
Externally published	Yes

Keywords

Autism symptoms
Classification
Phenotypic heterogeneity

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-014-2167-x

Cite this

Georgiades, S., Boyle, M., Szatmari, P., Hanna, S., Duku, E., Zwaigenbaum, L., Bryson, S., Fombonne, E., Volden, J., Mirenda, P., Smith, I., Roberts, W., Vaillancourt, T., Waddell, C., Bennett, T., Elsabbagh, M., & Thompson, A. (2014). Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6. Journal of autism and developmental disorders, 44(12), 3045-3055. https://doi.org/10.1007/s10803-014-2167-x

Georgiades, S, Boyle, M, Szatmari, P, Hanna, S, Duku, E, Zwaigenbaum, L, Bryson, S, Fombonne, E, Volden, J, Mirenda, P, Smith, I, Roberts, W, Vaillancourt, T, Waddell, C, Bennett, T, Elsabbagh, M & Thompson, A 2014, 'Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6', Journal of autism and developmental disorders, vol. 44, no. 12, pp. 3045-3055. https://doi.org/10.1007/s10803-014-2167-x

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AU - Bryson, Susan

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AU - Smith, Isabel

AU - Roberts, Wendy

AU - Vaillancourt, Tracy

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AU - Elsabbagh, Mayada

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Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6

Abstract

Keywords

ASJC Scopus subject areas

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