Modal shirts in acetylcholine receptor channel gating confer subunit-dependent desensitization

David Naranjo, Paul Brehm

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

During the transition from embryonic to adult skeletal muscle, a decreased mean channel open time and accelerated desensitization of nicotinic acetylcholine (ACh) receptors result from the substitution of an ε subunit for γ. A single ACh receptor channel of the embryonic type, expressed in Xenopus oocytes, interconverts between gating modes of short and long open time, whereas the adult receptor channel resides almost exclusively in the gating mode with short open time. Differences in the fraction of time spent in either gating mode account for the subunit dependence of both receptor open time and desensitization. Therefore, developmental changes in the kinetics of muscle ACh receptors may be imparted through subunit-dependent stabilization of intrinsic gating modes.

Original languageEnglish (US)
Pages (from-to)1811-1814
Number of pages4
JournalScience
Volume260
Issue number5115
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

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