Mitogenic effects of excitatory amino acids in the adult rat retina

JoséA A. Sahel, Daniel M. Albert, Simmons Lessell, Henry Adler, Terri L. McGee, Joan Konrad-Rastegar

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We studied the retinas of adult rats after the intravitreal injection of excitatory amino acids and ouabain. Kainic acid, domoic acid, N-methyl d-asparate and ouabain produced swelling and vacuolization of the outer plexiform, inner nuclear and inner plexiform layers and pyknosis. Mitoses were present in retinas treated with all agents other than N-methyl d-asparate. Rompun ketamine anesthesia blocked the mitogenic effects. Immunohistochemical labeling of both glial fibrillary acidic protein and S100 protein would indicate that the mitoses are occurring in glial cells. We suggest that the mitogenic effects are mediated through action on glial cationic channels, and might account for the reactive gliosis observed in some retinal lesions.

Original languageEnglish (US)
Pages (from-to)657-664
Number of pages8
JournalExperimental Eye Research
Volume53
Issue number5
DOIs
StatePublished - Nov 1991

Keywords

  • S100 protein
  • excitatory amino acids
  • glia
  • glial fibrillary acidic protein
  • kainic acid
  • ouabain

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Sahel, J. A., Albert, D. M., Lessell, S., Adler, H., McGee, T. L., & Konrad-Rastegar, J. (1991). Mitogenic effects of excitatory amino acids in the adult rat retina. Experimental Eye Research, 53(5), 657-664. https://doi.org/10.1016/0014-4835(91)90226-5