Mitochondrial dysfunction and oxidative stress in metabolic disorders — A step towards mitochondria based therapeutic strategies

Jasvinder Singh Bhatti, Gurjit Kaur Bhatti, P. Hemachandra Reddy

    Research output: Contribution to journalReview articlepeer-review

    229 Scopus citations

    Abstract

    Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca2 + regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases. Mitochondrial dysfunction and oxidative stress are largely involved in aging, cancer, age-related neurodegenerative and metabolic syndrome. In the last decade, tremendous progress has been made in understanding mitochondrial structure, function and their physiology in metabolic syndromes such as diabetes, obesity, stroke and hypertension, and heart disease. Further, progress has also been made in developing therapeutic strategies, including lifestyle interventions (healthy diet and regular exercise), pharmacological strategies and mitochondria-targeted approaches. These strategies were mainly focused to reduce mitochondrial dysfunction and oxidative stress and to maintain mitochondrial quality in metabolic syndromes. The purpose of our article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic syndromes. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy.

    Original languageEnglish (US)
    Pages (from-to)1066-1077
    Number of pages12
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Volume1863
    Issue number5
    DOIs
    StatePublished - May 1 2017

    Keywords

    • Cardiovascular disease
    • Metabolic syndrome
    • Mitochondria
    • Mitochondria-targeted antioxidants
    • Obesity
    • Oxidative stress
    • Pre-diabetes
    • Reactive oxygen species
    • Type-2-diabetes

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

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