Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Anders Fridberger, Tianying Ren, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the Guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the Guinea pig cochlear apex in two directions with minimal surgery. Furthermore, all prior vibration measurements in the Guinea pig apex involved opening an observation hole in the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here, this limitation is overcome by measuring the vibrations through the unopened otic capsule using phase-sensitive Fourier domain optical coherence tomography. The optically and surgically advanced method described here lays the foundation to perform minimally invasive investigation of speech-related signal processing in the cochlea.

Original languageEnglish (US)
Article number025003
JournalJournal of biomedical optics
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • cochlear vibration
  • optical coherence tomography
  • optical interferometry
  • phase-sensitive Fourier domain optical coherence tomography
  • probe
  • speech

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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