Minimal basilar membrane motion in low-frequency hearing

Rebecca L. Warren, Sripriya Ramamoorthy, Nikola Ciganovic, Yuan Zhang, Teresa M. Wilson, Tracy Petrie, Ruikang K. Wang, Steven Jacques, Tobias Reichenbach, Alfred Nuttall, Anders Fridberger

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears with intact low-frequency parts. These regions of the cochlea may function in ways different from the extensively studied high-frequency regions, where the sensory outer hair cells produce force that greatly increases the soundevoked vibrations of the basilar membrane. We used laser interferometry in vitro and optical coherence tomography in vivo to study the low-frequency part of the Guinea pig cochlea, and found that sound stimulation caused motion of a minimal portion of the basilar membrane. Outside the region of peak movement, an exponential decline in motion amplitude occurred across the basilar membrane. The moving region had different dependence on stimulus frequency than the vibrations measured near the mechanosensitive stereocilia. This behavior differs substantially from the behavior found in the extensively studied high-frequency regions of the cochlea.

Original languageEnglish (US)
Pages (from-to)E4304-E4310
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number30
DOIs
StatePublished - Jul 26 2016

Fingerprint

Basilar Membrane
Cochlea
Hearing
Vibration
Outer Auditory Hair Cells
Stereocilia
Interferometry
Speech Perception
Optical Coherence Tomography
Inner Ear
Music
Guinea Pigs
Lasers

Keywords

  • Basilar membrane
  • Hair cells
  • Hearing
  • Optical coherence tomography

ASJC Scopus subject areas

  • General

Cite this

Warren, R. L., Ramamoorthy, S., Ciganovic, N., Zhang, Y., Wilson, T. M., Petrie, T., ... Fridberger, A. (2016). Minimal basilar membrane motion in low-frequency hearing. Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4304-E4310. https://doi.org/10.1073/pnas.1606317113

Minimal basilar membrane motion in low-frequency hearing. / Warren, Rebecca L.; Ramamoorthy, Sripriya; Ciganovic, Nikola; Zhang, Yuan; Wilson, Teresa M.; Petrie, Tracy; Wang, Ruikang K.; Jacques, Steven; Reichenbach, Tobias; Nuttall, Alfred; Fridberger, Anders.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 30, 26.07.2016, p. E4304-E4310.

Research output: Contribution to journalArticle

Warren, RL, Ramamoorthy, S, Ciganovic, N, Zhang, Y, Wilson, TM, Petrie, T, Wang, RK, Jacques, S, Reichenbach, T, Nuttall, A & Fridberger, A 2016, 'Minimal basilar membrane motion in low-frequency hearing', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 30, pp. E4304-E4310. https://doi.org/10.1073/pnas.1606317113
Warren, Rebecca L. ; Ramamoorthy, Sripriya ; Ciganovic, Nikola ; Zhang, Yuan ; Wilson, Teresa M. ; Petrie, Tracy ; Wang, Ruikang K. ; Jacques, Steven ; Reichenbach, Tobias ; Nuttall, Alfred ; Fridberger, Anders. / Minimal basilar membrane motion in low-frequency hearing. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 30. pp. E4304-E4310.
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