Midluteal phase endometrial biopsy does not accurately predict luteal function

M. C. Batista, T. P. Cartledge, M. J. Merino, C. Axiotis, M. P. Platia, G. R. Merriam, Donald (Lynn) Loriaux, L. K. Nieman

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To investigate whether a midluteal phase endometrial biopsy accurately predicts luteal function. Design: One nonpregnant menstrual cycle was evaluated in a prospective fashion. Setting: Outpatient Clinic of the Clinical Center of the National Institutes of Health. Participants: Fifty healthy, normally cycling women. Interventions: Serum progesterone (P) was measured daily throughout the luteal phase. An endometrial biopsy was performed 7 to 9 days after the luteinizing hormone (LH) surge, as detected by rapid plasma assays, and dated histologically according to Noyes' criteria. Main Outcome Measure: To correlate endometrial maturation with luteal P secretion. Results: Mean integrated P measurements were reduced only when the lag between histologic and chronological dating was ≥3 days or ≥4 days, depending on whether chronological dates were assigned prospectively from the LH surge or retrospectively from the onset of next menses, respectively. However, these lags did not consistently predict deficient luteal function because subnormal integrated P secretion was seen in only 14% of women with these delays in endometrial maturation. Conclusions: Midluteal phase endometrial biopsy provides a crude test of luteal function that does not precisely distinguish luteal insufficiency.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalFertility and Sterility
Volume59
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Corpus Luteum
Biopsy
Luteinizing Hormone
Menstruation
Luteal Phase
National Institutes of Health (U.S.)
Menstrual Cycle
Ambulatory Care Facilities
Progesterone
Healthy Volunteers
Outcome Assessment (Health Care)
Serum

Keywords

  • endometrial biopsy
  • endometrium
  • luteal insufficiency
  • luteal phase
  • luteal phase defect
  • Progesterone

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Batista, M. C., Cartledge, T. P., Merino, M. J., Axiotis, C., Platia, M. P., Merriam, G. R., ... Nieman, L. K. (1993). Midluteal phase endometrial biopsy does not accurately predict luteal function. Fertility and Sterility, 59(2), 294-300.

Midluteal phase endometrial biopsy does not accurately predict luteal function. / Batista, M. C.; Cartledge, T. P.; Merino, M. J.; Axiotis, C.; Platia, M. P.; Merriam, G. R.; Loriaux, Donald (Lynn); Nieman, L. K.

In: Fertility and Sterility, Vol. 59, No. 2, 1993, p. 294-300.

Research output: Contribution to journalArticle

Batista, MC, Cartledge, TP, Merino, MJ, Axiotis, C, Platia, MP, Merriam, GR, Loriaux, DL & Nieman, LK 1993, 'Midluteal phase endometrial biopsy does not accurately predict luteal function', Fertility and Sterility, vol. 59, no. 2, pp. 294-300.
Batista MC, Cartledge TP, Merino MJ, Axiotis C, Platia MP, Merriam GR et al. Midluteal phase endometrial biopsy does not accurately predict luteal function. Fertility and Sterility. 1993;59(2):294-300.
Batista, M. C. ; Cartledge, T. P. ; Merino, M. J. ; Axiotis, C. ; Platia, M. P. ; Merriam, G. R. ; Loriaux, Donald (Lynn) ; Nieman, L. K. / Midluteal phase endometrial biopsy does not accurately predict luteal function. In: Fertility and Sterility. 1993 ; Vol. 59, No. 2. pp. 294-300.
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