Microvillous Inclusion Disease with Abundant Vermiform, Electron-Lucent Vesicles

Douglas Weeks, Craig W. Zuppan, Richelle Malott, Gary W. Mierau

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 3-month-old girl with congenital secretory diarrhea underwent a duodenal biopsy. Histologic study showed villous atrophy and large amounts of PAS-positive material within enterocyte cytoplasm. Despite a clinical suspicion of microvillous inclusion disease, 2 sessions of electron microscopy were unsuccessful in detecting the diagnostic inclusions. Instead, large aggregates of electron-lucent, vermiform membranous vesicles were observed in enterocyte cytoplasm, corresponding to the PAS-positive material. A third attempt at electron microscopy was successful in detecting small numbers of microvillous inclusions. These and other recently reported cases document an expanding spectrum of ultrastructural findings in this disease, including examples where the classic microvillous inclusions are overshadowed by other features.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalUltrastructural Pathology
Volume27
Issue number5
StatePublished - Sep 2003

Fingerprint

Enterocytes
Cytomegalovirus Infections
Electron Microscopy
Cytoplasm
inclusions
PAS
Electrons
cytoplasm
Electron microscopy
Atrophy
Diarrhea
electron microscopy
electrons
atrophy
Biopsy

Keywords

  • Congenital secretory diarrhea
  • Electron microscopy
  • Microvillous inclusion disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

Cite this

Microvillous Inclusion Disease with Abundant Vermiform, Electron-Lucent Vesicles. / Weeks, Douglas; Zuppan, Craig W.; Malott, Richelle; Mierau, Gary W.

In: Ultrastructural Pathology, Vol. 27, No. 5, 09.2003, p. 337-340.

Research output: Contribution to journalArticle

Weeks, Douglas ; Zuppan, Craig W. ; Malott, Richelle ; Mierau, Gary W. / Microvillous Inclusion Disease with Abundant Vermiform, Electron-Lucent Vesicles. In: Ultrastructural Pathology. 2003 ; Vol. 27, No. 5. pp. 337-340.
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